基于SSRIs药物治疗的针、灸抗抑郁效应研究  

Anti-depression effect of acupunctrue and moxibustion based on SSRIs medication

作　　者：姜劲峰[1] 徐蕾[1] 林燕红[1] 卢金花[1] 陈丽智[1] 孙亦农[1] 

机构地区：[1]南京中医药大学第二临床医学院,江苏南京210029

出　　处：《中国针灸》2012年第3期219-223,共5页Chinese Acupuncture & Moxibustion

基　　金：国家十一五科技支撑计划项目:2006BAI12B05-2;江苏省中医药管理局课题项目:LB09006

摘　　要：目的:验证选择性5-羟色胺再摄取抑制剂(SSRIs)类药物治疗基础上针、灸抗抑郁效应。方法:80例抑郁症患者随机分为针灸药物组(25例)、针刺药物组(25例)、药物组(30例)。3组均给予SSRIs类药物,在此基础上,针灸药物组予督脉导气针刺法,穴取百会、风府、大椎等,并温灸大椎、百会;针刺药物组仅予督脉导气针刺法。采用汉密尔顿抑郁(HAMD)量表于治疗前后评定总分和各因子评分,并评定疗效。结果:与药物组相比,针刺药物组与针灸药物组HAMD量表阻滞、睡眠、焦虑/躯体化因子评分和总分明显改善(P<0.05,P<0.01);与针刺药物组相比,针灸药物组进一步改善了HAMD量表中的睡眠因子、认知因子评分和总分(P<0.05,P<0.01)。3组愈显率分别为100.0%(25/25)、84.0%(21/25)、56.7%(17/30),针灸药物组优于针刺药物组(P<0.05),且两组均优于药物组(均P<0.01)。结论:SSRIs类药物治疗基础上针、灸存在一定的抗抑郁效应,且针灸并用疗效优于单纯针刺。Objective To verify ttle anti-depression effect of acupuncture and moxibustion based on the medica- tion with selective serotonin reuptake inhibitors （SSRIs）. Methods Eighty cases of depression were randomly di- vided into an acupuncture-moxibustion-medication group （25 cases）, an acupuncture-medication group （25 cases） and a medication group （30 cases）. SSRIs medication was administered in all of the three groups. Complementari ly, in acupuncturc-moxibustion medication group, the needling technique of qi conduction in the Governor Vessel was applied to Baihui （GV 20）, Fengfu （GV 16）, Dazhui （GV 14）, etc. Additionally, mild moxibustion was add ed at Dazhui （GV 14） and Baihui （GV20）. In acupuncture medication group, acupuncture for qi conduction in the Governor Vessel was only adopted. Hamilton Depression Scale （HAMD） was used for the evaluation of the totalscore, the score of each factor before and after treatment separately, and the therapeutic effects were observed a mong 3 groups. Results Compared with medication group, the scores of the factors as retardation, sleep, and anxietyfsomatization, as well as the total score were all apparently improved in the other two groups （P-Q0.05, P〈.~0.01）. （＇ompared with acupuncture nledication group, the scores of sleep and cognition factors as well as the total score in HAMD were much improved in acupuncture-moxibustion-medication group （P〈0.05, P〈0.01）. Tile remarkable effective rates were 100.0%（25/25）, 84.0% （21/25） and 56.7% （17/30） in the three groups sepa rately, in which, the result in acupunclure-moxibustion nledication group was superior to acupuncture-medication group （P〈0.05）, and the results of these two groups were superior to medication group （both P〈0.01）. Conehtsion Either acupunctrure or moxibustion has a definite anti-depression effect based on SSRIs medication, but the coordination of acu puncture and moxibustion achieves a superior efficacy as compared with simple acupunc

关 键 词：抑郁症 针灸疗法 督脉 选择性5-羟色胺再摄取抑制剂 随机对照试验 

分 类 号：R246.6[医药卫生—针灸推拿学]