延安地区乙型肝炎病毒基因型与干扰素抗病毒治疗的效果  

The relationship between HBV genotypes and the antiviral effects of interferon in Yan′an region

作　　者：古巧燕[1] 曾庆磊[1] 徐光华[1] 任迎全[1] 

机构地区：[1]延安大学附属医院感染科,716000

出　　处：《肝脏》2012年第1期25-27,共3页Chinese Hepatology

摘　　要：目的了解延安地区不同HBV基因型临床特征及其干扰素抗病毒治疗的效果。方法用PCR鉴定延安地区130例慢性乙型肝炎患者的HBV基因型,并对患者应用干扰素α-2b抗病毒治疗12个月,随访12个月,对治疗及随访资料进行回顾性分析。统计学处理采用χ2检验。结果延安地区HBV基因型以B、C基因型为最常见;B基因型HBeAg阳性率明显低于C基因型,且B+C基因型HBeAg阳性率也明显低于C基因型;B基因型与B+C基因型、B基因型与D基因型、C基因型与D基因型、D基因型与B+C基因型的HBeAg阳性率比较,差异均无统计学意义。B基因型对干扰素的完全应答率、持续应答率明显高于C基因型,而无应答率低于C基因型;B+C基因型的干扰素应答率低于B、C基因型。结论延安地区B、B+C基因型HBeAg阳性率明显低于C基因型;B基因型对干扰素的完全应答率高于C基因型,B+C基因型的干扰素应答率低于B、C基因。Objective To explore the clinical features and efficacy of antiviral theray of HBV genotypes in Yan′an region. Methods HBV genotypes were identified in 130 chronic hepatitis B patients with PCR method, who were treated with interferon alpha-2b antiviral therapy for 12 months and followed up for 12 months, and then the data on treatment and follow-up were studied retrospectively. Results 1.HBV genotype in Yan′an region commonly were B and C genotype;2.The HBeAg positive rate of HBV genotype B was significantly lower than that of genotype C, while genotype B＋C was also lower than genotype C;3. There was no significant difference in HBeAg positive rate between genotype B and B＋C, genotype B and D, genotype C and D, or genotype D and B＋C. 4. The complete response rate and sustained response rate of genotype B to interferon were significantly higher than those of genotype C, but its no response rate was lower than genotype C. 5. The interferon response rate of genotype B＋C was lower than genotype B and C. Conclusion The HBeAg positive rate of HBV genotype B and B＋C are significantly lower than genotype C in Yan′an region;HBV genotype B had a higher complete response rate to interferon than genotype C, and genotype B＋C had a lower one than genotype B and C did.

关 键 词：肝炎病毒 乙型 基因型 干扰素A-2B 

分 类 号：R512.62[医药卫生—内科学]