外源性p物质与黏着斑激酶、蛋白激酶B、核因子在瘢痕形成中的关联性  

Relevance between substance P and focal adhesion kinase,protein kinase B,and nuclear factorκB in Scar formation

作　　者：贾垚[1] 张宝林[1] 

机构地区：[1]山西医科大学第一临床医学院整形科,太原030001

出　　处：《中国医疗前沿》2012年第2期3-5,共3页China Healthcare Innovation

摘　　要：目的探讨外源性P物质与黏着斑激酶、蛋白激酶B、核因子在瘢痕形成中的关联性及时效性。方法采用适宜浓度外源性P物质作用于人胚胎成纤维细胞,应用westenblot蛋白定量观察不同时间段黏着斑激酶、蛋白激酶B、核因子变化情况。结果随着外源性P物质作用时间的延长,人胚胎成纤维细胞中黏着斑激酶、蛋白激酶B、核因子的表达逐渐升高,在30min达到高峰,并至少持续60min。结论外源性P物质可能通过黏着斑激酶、蛋白激酶B、核因子途径迅速起效,有效促进成纤维细胞增殖,从而促进瘢痕形成。Objective To study the relevance between substance P（SP） and focal adhesion kinase（FAK）,protein kinase B（PKB）,and nuclear factorκB（NFκB） in Scar formation.Methods The appropriate concentration SP role in human embryonic fibroblasts application westenblot protein quantitative change FAK,PKB,NF-κB observe different time periods.Results Along with the SP action the extension of time,people in the embryo of fiber cells into FAK,PKB,NF-κB expression gradually raised,in 30 min peak,and last for at least 60 minutes.Conclusion SP may pass FAK,PKB,NF-κB way to work quickly and effectively promote into fiber cell proliferation,so as to promote the scarring.

关 键 词：成纤维细胞 外源性P物质 黏着斑激酶 蛋白激酶B 核因子 瘢痕 

分 类 号：R619[医药卫生—外科学]