中药对急性冠脉综合征患者血清SCD_(40)L、hs-CRP水平的影响  

Traditional Chinese Medicine Herb on sCD_(40)L and hs-CRP in Acute Coronary Syndrome

作　　者：王光苏[1] 张玉琴[1] 谢美芳[1] 崔娜[1] 卞慧敏[1] 李镇[1] 岳煜[1] 丁海拔[1] 罗俊[1] 

机构地区：[1]南京中医药大学附属第二临床医学院,江苏南京210017

出　　处：《中国中医急症》2012年第3期349-350,376,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：江苏省中医药局科研课题(LZ09075)

摘　　要：目的观察急性冠脉综合征(ACS)患者可溶性CD40配体(sCD40L)、高敏C反应蛋白(hs-CRP)的变化及中药对其影响。方法将ACS患者随机分为治疗组(中药治疗组)和对照组(常规治疗组),比较治疗前后各组血清sCD40L、hs-CRP水平变化。结果两组治疗后sCD40L、hs-CRP均明显降低,治疗组下降幅度较对照组大,但差异无统计学意义;治疗组治疗后痰阻心脉证、心脉不通证、寒凝心脉证组和气阴两虚证sCD40L、hs-CRP均降低,阳气虚衰证无明显降低。结论中药治疗可降低ACS患者血清sCD40L及hs-CRP水平,不同证型,疗效有差异,辨证分型选择中药及其重要。Objective ：＇Fo observe traditional Chinese medicine herb on the serum soluble segmeng of CD4o ligand （sCD4oL） and the hypersensitive C-reactive protein （hs-CRP）in paitents with acute coronary syndrome （ACS）. Methods：40 patients with ACS were randomly divided into the treatment group of 20 patents with traditional Chinese medicine and the control group of 20 patients with conventional treatment. Contents of sCD~）L and hs- CRP in serum were measured and. compared in 2 groups. Results：These levels of serum sCD^J~ and hs-CRP after treatment were lower obviously than those before treatment. After therapy ,levels of serum sCD40L and hs-CRP were decreased significantly in the phlegm blocking heart vessel syndrome, the heart vessel obstruction syndrome, the cold stagnation in heart channel syndrome and the deficiency of both qi and yin syndrome. There was no significant decrease in the yang-qi deficiency syndrome. Conclusion：Traditional Chinese medicine can decrease the serum levels of sCD,~L and hsCRP in patients of ACS, The different TCM syndrome showed different effects.

关 键 词：急性冠脉综合征 可溶性CD40配体 超敏C反应蛋白 中药 

分 类 号：R541.4[医药卫生—心血管疾病]