针刺对戊四唑致痫大鼠海马神经元超微结构的影响  

Effect of Acupuncture on Ultrastructure of Hippocampal Neurons in Rats with Pentylenetetrazol-induced Epilepsy

作　　者：昂文平[1] 杨帆[1] 沈德凯[1] 刘向国[1] 

机构地区：[1]安徽中医学院,安徽合肥230038

出　　处：《中国中医急症》2012年第3期380-382,共3页Journal of Emergency in Traditional Chinese Medicine

基　　金：国家自然科学基金项目(81072872);安徽省自然科学基金项目(090413104)

摘　　要：目的观察针刺对戊四唑诱发癫痫大鼠海马神经元损伤的保护作用。方法将SD大鼠72只随机分为模型组、针刺组、正常组。正常组腹腔注射0.9%氯化钠注射液(2 mL)、其余各组腹腔注射戊四唑(50 mg/kg),于注射后4 h与24 h两个时间段取脑组织。分别于光镜下和电镜下观察海马结构改变。结果癫痫发作后4 h光镜、电镜均可见大鼠海马神经元损伤,24 h后损伤进一步加重;针刺组大鼠海马神经元损伤明显减轻。结论针刺具有明显保护癫痫继发脑神经元损伤作用。Objective：To observe the protection of acupuncture on hippocampal neurons injury in rats with epilepsy induced by pentylenetetrazoL Methods：72 SD rats were randomly divided into the epilepsy model group, the acupuncture treatment group and the normal group. Rats of normal group were intraperitoneally injected with the 2 mL of normal sodium. The rest of rats were intraperitoneally injected PTZ with 50 mg/kg. At 4 h and 24. h after injection,the 2 time periods of rats brain tissue were observed under microscope and electron microscope to get the message of changes in the hippocampal formation. Results：At 4 h after seizure ,rats hippocampal neurons injury was seen under microscopy and electron microscopy. At 24 h after seizure,the injury was further,hip- poeampal neurons injury was significantly reduced in acupuncture group. Conclusion：Acupuncture has obvious protective effect of epilepsy secondary to neuronal damage.

关 键 词：针刺 癫痫 神经元 超微结构 

分 类 号：R285.5[医药卫生—中药学]