基于组分结构假说构建中药药性矢量结构方程  

Establishment of drug property vectors equation of Chinese materia medica based on hypothesis of components structure

作　　者：蒋俊[1,2] 贾晓斌[1,3] 陈斌[1] 李平[2] 蔡宝昌[3] 吴浩[3] 

机构地区：[1]江苏省中医药研究院中药新型给药系统重点实验室国家中医药管理局中药口服释药系统重点研究室,江苏南京210028 [2]镇江出入境检验检疫局国家食品添加剂及调味品检测重点实验室,江苏镇江212008 [3]南京中医药大学江苏省中药炮制重点实验室,江苏南京210029

出　　处：《中草药》2012年第3期422-427,共6页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(30973944);江苏省中药炮制重点实验室开放课题(ZYPZ002);江苏省中医药领军人才专项课题(2006);江苏出入境检验检疫局项目(2011KJ48)

摘　　要：中药本身是一个复杂的整体,有其相应的物质基础,即相应的"组分结构",而中药药性即为中药中复杂的组分结构作用于人体后的综合体现。中药中的成分/组分可表现相应的药性属性(寒、热、温、凉),组分与组分之间以及组分内部都存在着药性差异。药性相同的成分/组分,表现为相互增强;药性相反者,则相互抵消,即可以用"矢量"表示,中药药性也就是各成分/组分"药性矢量"的"矢量加和"。在结合中药药性的最新研究方法和手段的基础上,将"组分结构"假说和"中药药性矢量"相结合,拟构建中药"药性结构方程"模型,以阐述中药药性本质。中药"药性矢量结构方程"模型的构建,也将为中药配伍以及炮制机制研究提供重要的研究思路和方法。Chinese materia medica（CMM） is a complex system which has its corresponding material base,that is components structure,and the drug property is the comprehensive effect of its complicated components structure on human beings.The compounds/constituents in each CMM may have the corresponding drug property（cold,hot,warm,and cool）.Different constituents（intra-or inter-） have different properties.Constituents/compositions with the same drug property could increase the drug property,while opposite could offset each other.Therefore,the property（cold or hot） could be demonstrated by vector.Drug property in each constituent/composition of CMM is the plus of each drug property vector.Based on the newest research methods of CMM drug property,the hypothesis of components structure was combined with CMM drug property vector to eatablish model of drug property vectors equation of CMM and explore the nature of drug property.This new thoughts will provide reference for study on compatibility and processing mechanism of CMM.

关 键 词：中药 药性 组分结构假说 药性矢量结构方程模型 炮制 

分 类 号：R285.1[医药卫生—中药学]