波棱甲素纳米混悬剂胶囊的制备及体外溶出度测定  

Preparation and dissolution determination of herpetrione nanosuspensions capsule

作　　者：郭静静[1,2] 李仙义[1] 袁海龙[1] 靳士晓[1,2] 韩晋[1] 

机构地区：[1]解放军第302医院,北京100039 [2]成都中医药大学药学院,四川成都611730

出　　处：《中草药》2012年第3期467-470,共4页Chinese Traditional and Herbal Drugs

基　　金：国家新药创制重大专项(2009ZX09103-349);国家教育部留学归国人员科研启动基金(20101561)

摘　　要：目的研究波棱甲素纳米混悬剂的制备及其胶囊体外溶出度的测定。方法采用高压均质法制备波棱甲素纳米混悬剂,并分别将波棱甲素纳米混悬剂和波棱甲素物理混合物制成胶囊,以pH 7.5的磷酸盐缓冲液为溶出介质,采用桨法测定体外溶出度,比较波棱甲素纳米混悬剂胶囊和波棱甲素物理混合物胶囊的溶出速率和溶出量。结果采用高压均质法制备的波棱甲素纳米混悬剂胶囊的体外累积溶出度明显高于波棱甲素物理混合物胶囊(P<0.01)。结论高压均质法制备波棱甲素纳米混悬剂的工艺简单易行,波棱甲素纳米混悬剂能显著提高药物的体外溶出度。Objective To study the preparation process for herpetrione nanosuspensions and the determination of dissolution rate of the herpetrione nanosuspensions capsule.Methods Herpetrione nanosuspensions were prepared by the high pressure homogenization technology.Using phosphate buffer（pH 7.5） as dissolvent,the dissolution rate and the dissolution amount of herpetrione from the nanosuspensions capsule as well as the physical mixture capsule were determined and compared by the paddle method.Results The in vitro accumulated dissolution of herpetrione nanosuspensions capsule prepared by the high pressure homogenization technology is higher than that of the physical mixture capsules（P0.01）.Conclusion The high pressure homogenization technology employed to prepare herpetrione nanosuspensions is feasible and herpetrione nanosuspensions can improve the in vitro dissolution rate notablely.

关 键 词：波棱甲素 纳米混悬剂 溶出度 高压均质法 桨法 

分 类 号：R284.2[医药卫生—中药学]