四项指标联合检测在细菌性感染疾病中的诊断意义  

The diagnostic significance of the joint detection of 4 indicators in bacterial infective disease

作　　者：陈华英[1] 林伟华[1] 何艳[1] 洪流[1] 宁丹霞[1] 

机构地区：[1]广东省湛江中心人民医院,524037

出　　处：《实用医技杂志》2012年第3期238-240,共3页Journal of Practical Medical Techniques

摘　　要：目的探讨细菌性感染疾病患者血清超敏C反应蛋白(hs-CRP)、白细胞、中性粒细胞分类及中性粒细胞碱性磷酸酶(NAP)变化的相关性。方法采用免疫比浊法测定hs-CRP、血细胞分析仪法测定白细胞及中性粒细胞分类、偶氮偶联法检测NAP;选取133例细菌性感染疾病患者作为感染组,60名健康体检者作为对照组。结果感染组hs-CRP、白细胞、中性粒细胞分类、NAP及NAP积分均高于对照组(P<0.01)。感染组CRP水平升高有130例,白细胞升高有118例,NAP升高有126例,中性粒细胞分类升高有116例,hs-CRP+白细胞+中性粒细胞分类+NAP积分4项指标联合检测有131例升高。结论血清hs-CRP、白细胞、中性粒细胞分类及NAP检测是感染性疾病早期鉴别诊断快速有效的诊断指标之一,CRP及NAP浓度的监测对细菌性感染的早期诊断,比白细胞计数更敏感,联合检测有利于提高诊断率。Objective To explore the pertinence of the joint detection of serum high sensitivity C-reactive protein （hs-CRP）, white blood cell （WBC）, neutropenia （NC） classification and neutrophil alkaline phosphatase （NAP） in patients who were infected by bacteria. Methods Immune turbidimetrie method was used to determine the level of hs- CRP. Blood cell analyzer was applied to determine the WBC and NC classification. AZO coupling method was used to detect of NAP; 133 patients with bacterial infections as infection group, 60 cases of healthy people as control group. Results Infection group hs-CRP, WBC, NC, NAP and NAP integral classification were higher than that of control group （P〈O.01）. Infection group CRP concentration was elevated in 130 patients, high levels of white blood cells in 118 cases, NAP 126 cases of NC classification of elevated, elevated in 116 eases, hs-CRP＋WBC＋NC＋NAP integral classification of 4 indexes of combined detection of 131 cases of elevated. Conclusion The serum hs-CRP, WBC, NC classification and NAP detection is infectious disease early differential diagnosis and fast and effective diagnosis index. CRP and NAP concentration monitoring in early diagnosis of bacterial infection is more sensitive than WBC count and helpful to improve the diagnosis rate of combined detection.

关 键 词：C反应蛋白质 白细胞计数 中性粒细胞分类 中性粒细胞碱性磷酸酶 细菌感染 

分 类 号：R446.11[医药卫生—诊断学]