黄瓜根化学成分研究  

Study on chemical constituents of cucumber roots

作　　者：王亚敏[1] 罗怀浩[1] 谢辉[1] 裴刚[1] 邓益媛[1] 周小江[1] 

机构地区：[1]湖南中医药大学药学院,湖南长沙410208

出　　处：《湖南中医药大学学报》2012年第1期35-37,共3页Journal of Hunan University of Chinese Medicine

基　　金：湖南省科技厅资助项目(2009FJ3213)

摘　　要：目的研究黄瓜根的化学成分。方法采用硅胶柱层析和Sephadex LH-20凝胶柱层析进行分离纯化,通过理化性质和波谱数据分析进行结构鉴定。结果从黄瓜根的乙酸乙酯提取物中分离了11个化合物,分别为:豆甾-4,6,8(14),22-四烯-3-酮(Ⅰ)、dehydroeburicoic acid(Ⅱ)、α-菠甾醇-3-O-β-D-葡萄糖苷(Ⅲ)、乌苏酸(Ⅳ)、3β-Hydroxy-multiflora-8-en-17-oic acid(Ⅴ)、Indolyl-3-acetic acid methyl ester(Ⅵ)、1-H-3-吲哚羧酸甲酯(Ⅶ)、吲哚醛(Ⅷ)、邻羟基苄醇(Ⅸ)、异香草醛(Ⅹ)和对羟基苯甲醛(Ⅺ)。结论除化合物Ⅲ外,其余化合物均为首次从该植物中分离得到。Objective To study the chemical constituents in roots of cucumber.Methods The chemical constituents were isolated and purified by silica gel and Sephadex LH-20 column chromatography,their structures were elucidated by the analysis of spectral data and chemical properties.Results Eleven compounds were isolated from EtOAc extract and their structures were identified as stigmasta-4,6,8（14）,22-tetraen-3-one（Ⅰ）,dehydroeburicoic acid（Ⅱ）,α-spinasterol-3-O-β-D-glucopyranoside（Ⅲ）,ursolic acid（Ⅳ）,3β-Hydroxymultiflora-8-en-17-oic acid（Ⅴ）,Indolyl-3-acetic acid methyl ester（Ⅵ）,methyl 1H-indole-3-carboxylate（Ⅶ）,1H-Indole-3-aldehyde（Ⅷ）,2-hydroxybenzyl alcohol（Ⅸ）,isovanillin（Ⅹ） and p-hydroxybenzaldehyde（Ⅺ）.Conclusion These compounds were isolated from roots of Cucumis sativus L.for the first time except for α-spinasterol-3-O-β-D-glucopyranoside.

关 键 词：黄瓜根 化学成分 结构鉴定 

分 类 号：R284.1[医药卫生—中药学]