CPI-5缓蚀剂的小鼠急性经口毒性分析  

Acute Oral Toxicity Test on Mouse of CPI-5 Corrosion Inhibitor

作　　者：梁俊奕[1] 上官昌淮[2,3] 赵华莱[2,3] 杨笑曦[4] 李春美[5] 

机构地区：[1]西南石油大学石油工程学院,成都610500 [2]中国石油集团工程设计有限责任公司西南分公司,成都610017 [3]中国石油天然气集团公司石油管力学和环境行为重点实验室四川研究室,成都610017 [4]武汉大学医学院,武汉430071 [5]华中农业大学,武汉430070

出　　处：《四川理工学院学报（自然科学版）》2012年第1期27-30,共4页Journal of Sichuan University of Science & Engineering(Natural Science Edition)

基　　金：国家"十二五"科技重大专项(2011ZX-05059);中国石油天然气集团公司工程建设分公司科学研究与技术开发项目(2011GJTC-09-01)

摘　　要：为适应油气田现场化学剂使用时QHSE发展趋势,确保油气田现场用化学助剂安全无毒无污染的性能特点,采用小白鼠毒性测试研究了现场用化学剂的毒性。通过采用灌胃的方法,研究了CPI-5缓蚀剂对小鼠的急性毒性。一次性给药后连续观察7天,检测CPI-5缓蚀剂对小鼠的急性毒性作用,包括最小致死剂量和半数致死量。实验结果表明:CPI-5缓蚀剂灌胃给小鼠的最小致死剂量约为14.9 g/kg体重,半数致死剂量约为30.45 g/kg体重,因此CPI-5缓蚀剂属于无毒或微毒的化学剂,能够适用于油气田现场推广,同时无毒无害缓蚀剂运用于现场对于改善现场操作环境和保证员工的健康具有重要的意义。Base on the QHSE of chemicals used in the oil and gas field, in order to prevent the oil and gas field from polluting, the toxicity of the chemicals testing on mice was studied. The acute oral toxicity of CPI-5 corrosion inhibitor on mouse was tested by a disposable dosage giving chemical after giving chemical 7-days and continuous observation on mousse carried out for the minimum lethal dose ＆ median lethal dose analysis of CPI-5 corrosion inhibitor. The result shows that the minimum lethal dose ＆ LD50 of CPI-5 corrosion inhibitor were about 14. 9g/kg weight and 30. 45g/kg weight, so CPI-5 corro- sion inhibitor was defined as non-toxic or low toxicity, and it could be widely used in oil and gas field. Due to the non-tixic or low toxicity of the corrosion inhibitor in the oil and gas field, it was very important to operation environment and healthy of employees.

关 键 词：缓蚀剂 灌胃 最小致死剂量 半数致死剂量 

分 类 号：R991[医药卫生—毒理学]