六味地黄汤生物制剂对小鼠耐寒、耐缺氧及抗疲劳作用的实验研究  

Effect of Liuweidihuang metabolized by photosynthetic bacteria on cold-tolerance and oxygen deficit-tolerance and anti-fatigue in mouse

作　　者：丘婷[1] 李天河[1] 吴思[1] 汤佩莲[1] 赵越[1] 

机构地区：[1]广东药学院中药学院,广东广州510006

出　　处：《广东药学院学报》2011年第6期621-623,共3页Academic Journal of Guangdong College of Pharmacy

基　　金：广东省自然科学基金重点项目(825022401000006);广州市科技局项目(2008Z1-E381)

摘　　要：目的观察六味地黄汤生物制剂对小鼠耐寒、耐缺氧、抗疲劳的影响。方法昆明种小鼠随机分为空白对照组、六味地黄汤阳性对照组及六味地黄汤生物制剂低、中、高(2.4、4.8、9.6 g/kg)剂量组,灌胃给药7 d后分别考察小鼠-5℃寒冷的死亡率、常压耐缺氧时间以及负重游泳时间。结果六味地黄汤生物制剂能明显降低小鼠-5℃寒冷的死亡率(P<0.05),延长常压耐缺氧时间以及负重游泳时间。结论六味地黄汤生物制剂具有良好的耐寒、耐缺氧、抗疲劳作用。Objective To investigate the effect of Liuweidihuang metabolized by photosynthetic bacteria（LW-PSB） on murine resistance against cold,oxygen deficit and fatigue.Methods KM mice were randomly divided into five groups,including the negative control group,positive control group（Liuweidihuang metabolized） and three LW-PSB-treated groups（2.4,4.8 and 9.6 g/kg）.After 7 days,stress response was tested.Results LW-PSB obviously shortened the mortality rate of mice at-5 ℃ and lengthened the time of mice at oxygen deficit as well as weight-bearing swimming.Conclusion LW-PSB affords an important role in resistance to cold,oxygen deficit and fatigue in mice.

关 键 词：六味地黄汤生物制剂 耐寒 耐缺氧 抗疲劳 

分 类 号：R285.5[医药卫生—中药学]