胆固醇7α-羟化酶调节的研究进展  

Research progress of the regulation to cholesterol 7α-hydroxylase related to lipid metabolism

作　　者：曹扬[1] 贝伟剑[1] 

机构地区：[1]广东药学院中医药研究院/国家中医药管理局脂代谢三级实验室及高脂血症调肝降脂重点研究室,广东广州510006

出　　处：《广东药学院学报》2011年第6期658-661,共4页Academic Journal of Guangdong College of Pharmacy

基　　金：国家自然科学基金(30973913;81173626);国家科技重大专项(2009ZX09103-407)

摘　　要：胆固醇7α-羟化酶(cholesterol 7α-hydroxylase,CYP7A1)是在肝脏合成并促使胆固醇转化成胆酸的限速酶,对维持体内胆固醇代谢平衡起到关键作用。CYP7A1基因表达受脂代谢相关的多个核因子的精细调控,诸如HNF4a,LXR,FXR,SHP和FGF15/19及相关激素等其他因子,以维持胆固醇代谢平衡;多种中药及饮食成分对CYP7A1的基因表达也有明显调节作用,进而影响血脂代谢。本文就近10年来有关CYP7A1调节的研究进展综述如下。Cholesterol 7α-hydroxylase（CYP7A1）,synthesized in liver,is the rate-limiting enzyme that induces cholesterol converse to bile acid,and it plays a vital role in keeping homeostasis of cholesterol metabolism.The expression of CYP7A1 is well controlled by nuclear factors that related to lipid metabolism such as HNF4a,LXR,FXR,SHP,FGF15/19 and other hormones.Some traditional Chinese medicine and food ingredients also show regulation to CYP7A1.This paper will make a summary for references about the related research progress on CYP7A1 in recent decades.

关 键 词：胆固醇7α-羟化酶(CYP7A1) 胆固醇代谢 核受体 基因表达调控 中药 

分 类 号：R341[医药卫生—基础医学]