他汀类药物对急诊PCI术后心室跨壁复极离散度及室性心律失常的影响  被引量:2

Influence of statins on transmural dispersion of repolarization and ventricular arrhythmia in patients underwent emergency PCI

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作  者:杨培根[1] 董国峰[2] 杨琦[1] 陈炳伟[1] 吴尚勤[1] 

机构地区:[1]天津市胸科医院心内科,天津300051 [2]天津医科大学研究生院,天津300070

出  处:《中国现代医学杂志》2011年第36期4551-4554,共4页China Journal of Modern Medicine

摘  要:目的探讨大剂量阿托伐他汀(80 mg)对ST段抬高性急性心肌梗死患者急诊PCI术后心室跨壁复极离散度及室性心律失常的影响。方法将该院2009年9月~2011年6月住院行急诊PCI术治疗的ST段抬高性急性心肌梗死患者161例随机分为他汀组80例和非他汀组81例,另设对照组75例。他汀组在入院后即刻口服阿托伐他汀80 mg,急诊PCI术后3 d内每日口服阿托伐他汀40 mg。然后分别测定并比较3组患者入院即刻、第2天、第3天校正的跨壁复极离散度值,并根据动态心电图检测结果比较3组恶性室性心律失常的发生率。结果 (1)急性心肌梗死患者较正常组心室跨壁复极离散度明显增加(P<0.01)、恶性室性心律失常的发生率亦明显增加(P<0.01)。(2)他汀组较非他汀组心室跨壁复极离散度的明显减小(P<0.05),但恶性室性心律失常的发生率尚无统计学差异(P=0.07)。结论 ST段抬高性急性心肌梗死患者心室跨壁复极离散度值及恶性室性心律失常的发生率显著增加;大剂量阿托伐他汀能减小ST段抬高性急性心肌梗死患者急诊PCI术后心室跨壁复极离散度。[ Objective] To study the influence of high dose atorvastatin (80 mg) on transmural dispersion of repolarization and malignant ventricular arrhythmia in patients with ST segment elevated acute myocardial infarction underwent emergency percutaneous coronary intervention (PCI). [Methods ] Before emergency PCI, 161 cases with ST segment elevated acute myocardial infarction from September 2009 to June 2011 were randomly divided into two groups: statin group (80 cases) and non-statin group (81 cases); and 75 'cases of control were enrolled randomly (control group). The patients of statin group received atorvastatin 80 mg orally instantly before emergency PCI and 40 mg once a day after emergency PCI in three days. Then according to hoher outcomes, the values of corrected TDR (TDRc) and the incidence rate of malignant ventricular arrhythmia (MVA) were measured and compared instantly before emergency PCI, on the second day and the third day after emergency PCI between groups. [Results] (1) The values of TDRc and incidence rate of malignant ventricular arrhythmia in patients with ST segment elevated acute myocardial infarction was much higher than the corresponding values in control group (P 〈0.01); (2) The values of TDRc in statin group was significantly lower than non-statin group, whereas there was no significant difference of incidence rate of malignant ventricular arrhythmia between the two groups (P =0.07). [ Conclusion] The values of TDRc and incidence rate of malignant ventricular arrhythmia were significantly higher in patients with ST segment elevated acute myocardial infarction; high dose atorvastatin can decrease the values of TDRc in patients with ST segment elevated acute myocardial infarction underwent emergency PCI.

关 键 词:他汀 心肌梗死 急诊PCI 跨壁复极离散度 恶性室性心律失常 

分 类 号:R54[医药卫生—心血管疾病]

 

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