CRMPs对神经元突起生长的调控  

Regulation of neurite outgrowth by collapsin response mediator proteins in neurons

作　　者：郭国庆[1] 张吉凤[1] 纪志盛[1] 

机构地区：[1]暨南大学医学院解剖学教研室,广东广州510632

出　　处：《暨南大学学报（自然科学与医学版）》2011年第6期557-561,共5页Journal of Jinan University(Natural Science & Medicine Edition)

基　　金：国家自然科学基金项目(31170941);广东省科技计划项目(2010B031600102)

摘　　要：神经元突起是建立神经网络的物质基础,其生长为生长信号启动胞内信号促使神经元不断极化的过程。作为Rho GTPases的下游信号,CRMPs富集于神经系统,参与神经元的发育过程,可作为不同信号通路的共同受体后分子,通过改变细胞骨架的运动调控突起生长。其不同亚基的功能分化、不同亲和性特点显示其具有突起生长调控的分子开关特征,有效地控制突起的生长不仅是发育神经生物学的基本问题,也为重建因神经损伤和退行性疾病受到破坏的神经网络提供可行的作用靶点。Neurites branching out from the soma create an intricate neural network. As a basis of thenetwork, neurite outgrowth is a complex process of neural polarity involving downstream intracellular ef-fectors triggered by growth and guidance factors. All collapsin response mediator proteins （CRMPs） aredevelopmentally regulated proteins and they are strongly expressed in neural cells. CRMPs are involved inregulation of neurite outgrowth as key downstream effector molecules of Rho GTPases and each familymember of CRMPs plays a distinct role in neurite outgrowth by regulating cytoskeleton. Because of thedistinct role of each family member and their different binding affinities, CRMPs may act as a molecularswitch that controls the neurite outgrowth by regulating the organization and dynamics of the cytoskeleton.Neurite outgrowth is not only a fundamental cellular process but also an important clinical concern. In or-der to find a new target in neural regeneration for restoring damaged neural network induced by injury anddegeneration, it is critical for us to interpret the basic phenomenon that CRMPs regulate neurite out-growth.

关 键 词：坍塌反应调节蛋白 神经元 细胞骨架 突起 生长 

分 类 号：Q189[生物学—神经生物学] Q954.67[生物学—普通生物学]