组织工程支架材料的研究进展  

Progress in Study of Scaffolds for Tissue Engineering

作　　者：李昱辉[1] 卢婷利[1] 校月红[1] 陈婷[1] 陈涛[1] 

机构地区：[1]西北工业大学生命学院空间生物实验模拟技术国防重点学科实验室,陕西西安710072

出　　处：《中国材料科技与设备》2011年第5期15-18,共4页Chinese Materials Science Technology & Equipment

基　　金：国家自然科学基金资助项目（20872119）,陕西省自然科学基金资助项目（2010JM2021）

摘　　要：自19世纪以来，移植手术一直致力于修复由于创伤﹑感染﹑肿瘤所造成的大范围组织缺损，以恢复器官功能。自体移植是目前最常采用的疗法，但供体的有限性限制了其应用，而且会给患者带来很大的痛苦。组织工程的目标是通过种子细胞在三维支架材料上的黏附﹑生长进而修复受损的组织。三维支架是种子细胞形成组织之前赖以生存和依附的载体，能够正确引导新组织的生长。因此支架材料的选择就成了关键，本综述主要介绍目前应用于组织工程的生物支架材料的性能要求﹑发展现状以及发展前景。Thousands of surgical procedures are performed to replace or repair tissue that has been damaged through trauma, tumor or infection since 19th century. Treatment typically focuses on transplanting tissue from one site to another using the autograft, but harvesting autografts is painful and constrained by a few suitable donors. The developing field of tissue engineering （TE） aims to regenerate damaged tissue by combing cells from the body with highly porous scaffold biomaterials, which act as templates allowing cells to migrate, adhere, and produce tissue. The choice of different biomaterials is very important. This article describes the functional requirements, and types, of materials used in developing state of the art of scaffolds for tissue engineering applications.

关 键 词：组织工程 三维支架 孔隙结构 细胞黏附 

分 类 号：Q819[生物学—生物工程]