盐酸曲马多缓释滴丸兔体内药动学研究  

The study of pharmacokinetic of tramadol hydrochloride sustained-release dropping pills in rabbits

作　　者：智成芳[1] 姜言丽[1] 曲韵智 景舒[1] 

机构地区：[1]内蒙古医学院药学院,呼和浩特010110 [2]北京正大绿洲制药有限公司,北京101113

出　　处：《天津药学》2012年第1期1-4,共4页Tianjin Pharmacy

基　　金：内蒙古自治区自然科学基金项目(No.20080404MS1206)

摘　　要：目的:比较盐酸曲马多缓释滴丸与普通片剂在兔体内的药代动力学和生物利用度。方法:以普通片为对照,采用高效液相色谱法测定兔体内的血药浓度。结果:缓释滴丸和普通片的药-时曲线下面积分别为(6 567.71±231.69)ng/ml.h和(5 954.87±93.85)ng/ml.h;缓释滴丸的Cmax、Tmax分别为542 ng/ml和5.25 h;普通片分别为953 ng/ml和2h。结论:缓释滴丸比普通片能持久维持平稳的血药浓度,增强了用药的有效性和安全性。Objective：Through the test sustained- release and reference products available tablets in rabbits of pharmacokinetics and Bioavailability studies to demonstrate the test in comparison with commercially available tablets showed sustained release characteristics. Methods ： An HPLC system using a liduid - liquid extraction and UV detection had been validated to determine Tramad- ol Hydrochloride concentration in plasma and commercial tablets were used as the reference. Results： The AUC of Tramadol Hydrochloride sustained -release dropping pills and reference tablets were （6 567.71 ± 231.69） ng/ml · h and （5 954.87 ±93.85） ng/ml · h respectively. The Cmax and Tmax of Tramadol Hydrochloride sustained - release dropping pills were 542 ng/ml and 5.25 h. The Cmax and Tmax of reference tablets were 953 ng/ml and 2 h. Conclusion： Sustained - release pills can maintain more stable than the conventional tablets plasma concentrations, enhance the effectiveness and safety of medication

关 键 词：盐酸曲马多 缓释滴丸 药动学 生物利用度 

分 类 号：R965[医药卫生—药理学]