奥美拉唑与法莫替丁治疗十二指肠溃疡疗效的荟萃分析  

Meta analysis of efficacy of omeprazole versus famotidine in treatment of duodenal ulcer

作　　者：陈月[1] 曲连悦[1] 李晓赫[1] 冯婉玉[1] 

机构地区：[1]中国医科大学附属第一医院药学部,沈阳110001

出　　处：《药学服务与研究》2012年第1期67-69,共3页Pharmaceutical Care and Research

基　　金：国家"十一五"科技支持计划重点项目(No.2009BAI76B03)

摘　　要：目的:评价奥美拉唑和法莫替丁治疗十二指肠溃疡的临床疗效和安全性。方法:检索中国知网(CNKI)、维普资讯网(VIP)、中国生物医学文献数据库(CBM)、PubMed、EMBase、the Cochrane Library数据库1990-2011年的相关文献,收集奥美拉唑与法莫替丁治疗十二指肠溃疡的随机对照临床研究。筛选符合纳入标准的临床研究,应用Juni评分法进行评价。以RevMan 5.0软件对相关数据进行荟萃(Meta)分析,采用漏斗图分析发表偏倚。结果:根据标准筛选出11篇文献:3篇C级,2篇B级,6篇A级。荟萃分析结果显示:奥美拉唑治疗十二指肠溃疡的2周愈合率OR=4.26,95%CI=(2.87,6.33),P<0.05;4周愈合率OR=2.62,95%CI=(1.87,3.67),P<0.05。两种药物导致的药品不良反应发生率无显著性差异。结论:与法莫替丁相比,奥美拉唑具有起效迅速和溃疡愈合率高的优点,是治疗十二指肠溃疡的优选药物。Objective： To evaluate the clinical efficacy and safety of omeprazole and famotidine in treatment of duodenal ulcer.Methods： Related literature in Chinese National Knowledge Infrastructure（CNKI）,VIP database,Chinese Biomedical Literature Database（CBM）,PubMed,EMBase and the Cochrane Library database during 1990 to 2011 was collected.Randomized control trials using omeprazole and famotidine for treatment of duodenal ulcer were selected and evaluated by Juni method.Meta analysis was performed by using RevMan 5.0 software and publication bias was analyzed by funnel plots.Results： According to the selection criteria,11 literature was selected,of which three was in Grade C,two in Grade B and six in Grade A.Meta analysis indicated that omeprazole was superior to famotidine with higher healing rates at week 2： OR=4.26,95%CI=（2.87,6.33）,P〈0.05 and at week 4：OR=2.62,95%CI=（1.87,3.67）,P〈0.05.There was no significant difference in the incidence of adverse drug reactions between two drugs.Conclusion： Compared with famotidine,omeprazole has advantages of rapid onset and high healing rate.Therefore,omeprazole is the better choice for treatment of duodenal ulcer.

关 键 词：奥美拉唑 法莫替丁 十二指肠溃疡 荟萃分析 

分 类 号：R975.2[医药卫生—药品]