112例银屑病患者生理和心理变化的临床观察  

Clinical Observation of Physiological and Psychological Changes in 112 Cases with Psoriasis

作　　者：王骏[1] 刘太华[1] 张忠奎[1] 罗陈[1] 

机构地区：[1]成都军区总医院皮肤科,610083

出　　处：《西南军医》2012年第1期1-3,共3页Journal of Military Surgeon in Southwest China

摘　　要：目的观察银屑病患者生理和心理变化情况以及与病情严重程度的关系。方法对在我院就诊的112例排除其他疾病的银屑病患者,进行银屑病严重程度评分(PASI),采用ZUNG抑郁自评量表(SDS)和ZUNG焦虑自评量表(SAS)测评患者抑郁和焦虑程度。检测血尿常规、肝功、肾功、血糖血脂、血液流变学和性激素,对PASI与抑郁评分、焦虑评分及临床检测指标进行相关分析。结果银屑病患者表现为明显的抑郁和焦虑,血常规、肝肾功、血糖血脂、血液流变学和性激素等检查中有多个指标明显异常;PASI与SAS和E2(雌二醇)呈正相关。结论银屑病的发病可能与心理因素和雌激素E2有关,可能会引起多个器官或系统的功能变化。Objective To observe the relationship between physiological and psychological changes and disease severity. Meth. otis Psoriasis Area and Severity Index （PASI） was made to 112 hospitalized cases with psoriasis but no other diseases; their depression degree and anxiety degree were evaluated by ZUNG Self - Rating Depression Scale （SDS） and ZUNG Self - Rating Anxiety Scale （SAS） ; blood and urine routine, liver and renal function, blood glucose and blood lipid, hemorhelogical changes and sex hormone were detected, correlative analysis was made between PASI, depression scores, anxiety scores and clinical detection index. Result The patients with psoriasis showed out obvious symptoms of depression and anxiety, and their index of clinical lab detection were abnormal ~ a positive correlation existed between PASI and SAS as well as between PASI and E2. Conclusions The pathogenesis of psoriasis is likely in certain relationship with psychological factors and E2, which may lead to functional changes of multi organs or systems.

关 键 词：银屑病 抑郁指数 焦虑指数 生理功能 性激素 血液流变学 

分 类 号：R758.63[医药卫生—皮肤病学与性病学]