老年高血压患者昼夜节律与同型半胱氨酸水平的关系研究  

Circadian Rhythm in Elderly Hypertensive Patients With Homocysteine Levels Relations

作　　者：孙俐俐[1] 王丽娜[1] 段丽敏[1] 邢福艳[1] 孙丹[1] 

机构地区：[1]大庆油田总医院,黑龙江大庆163001

出　　处：《中外医疗》2012年第5期11-12,共2页China & Foreign Medical Treatment

摘　　要：目的探讨老年高血压患者动态血压昼夜节律与同型半胱氨酸(Hcy)水平的关系。方法应用24h动态血压监测仪监测80例年龄≥60岁的高血压病患者的血压水平,根据夜间血压下降率将患者分为非杓型组46例和杓型组34例。采用酶联免疫分析法(ELISA)测定同型半胱氨酸的水平。结果杓型组夜间SBP和夜间DBP均明显低于非杓型组(P<0.01)。夜间血压下降率差异有非常显著性(P<0.01)。非杓型组同型半胱氨酸水平为(27.31±7.54)umol/L,明显高于勺型组(18.11±4.56)umol/L(P<0.01)。结论血压节律的异常可作为高血压患者靶器官受损状况评估的一项指标,对于预防和降低高血压病的并发症的发生有重要的临床意义。昼夜节律异常的老年高血压患者动脉粥样硬化更明显,更易导致靶器官损害。Objective To investigate ambulatory blood pressure in elderly hypertensive patients with circadian rhythm and homocysteine （Hey） levels relationship. Methods 24h ambulatory blood pressure monitor to monitor 80 cases aged^60 years of hypertensive patients blood pressure levels, according ;to the rate of decline in nocturnal blood pressure patients were divided into non--dipper and dipper group of 46 cases of 34 patients.By enzyme--linked immunosorbent assay（ELISA） determination of homocysteine levels.Results Dipper at night SBP and nighttime DBP group were significantly lower than non--dipper group（P〈0.01）.Rate of decline in nocturnal blood pressure difference was significant（P〈0.01）. Non--dipper group horaocysteine levels（27.31 ± 7.54umol//L）,significantly higher than the spoon--type group（18.11±4.56 umol/L）（P〈0.01）.Conclusion The circadian rhythm abnormalities in elderly patients with atherosclerosis, hypertension is more obvious, more likely to cause target organ damage.

关 键 词：高血压 血压昼夜节律 同型半胱氨酸 

分 类 号：R544.1[医药卫生—心血管疾病]