肿瘤自噬效应及其在非小细胞肺癌分子靶向治疗中的潜在应用  

Autophagic effect on tumor and its potential applicationsin non-small cell lung cancer molecular targeted therapy

作　　者：陈美娟[1] 詹瑧[1] 张旭[1,2] 

机构地区：[1]南京中医药大学基础医学院中西医结合基础学科 [2]江苏省方剂研究重点实验室,江苏南京210046

出　　处：《中国药理学通报》2012年第3期300-303,共4页Chinese Pharmacological Bulletin

基　　金：国家"十一五"科技支撑计划(No 2006BAI11B08-01);江苏省高校优势学科建设工程项目

摘　　要：目前针对非小细胞肺癌(NSCLC)的手术、放化疗等治疗手段临床疗效仍很不足,相应的分子靶向治疗药物随着临床抗药性的产生疗效也明显下降。自噬对肿瘤进展具有双重影响作用。在NSCLC临床治疗的各个阶段都应充分考虑自噬效应所起的作用,对其进行合理调节和利用,从而提高各种治疗手段的临床疗效。Now clinical treatments for non-small cell lung cancer（NSCLC） such as surgery,radiotherapy,and chemotherapy are still insufficient,and the efficacy of some molecular targeted therapy is also limited because of natural and acquired resistance in clinics.Autophagy exhibited the effects of a double-blade sword on tumor progression.On the one hand,autophagic can induce the death of tumor cells,and on the other hand,it also protects the tumor in stress such as nutritional deficiency.Clinical treatment of NSCLC at various stages should take full account of autophagic effect on its progression,which can improve the clinical efficacy of various treatments by reasonable combination.

关 键 词：自噬 肿瘤 分子靶向治疗 NSCLC 信号通路mTOR 

分 类 号：R329.25[医药卫生—人体解剖和组织胚胎学] R730.2[医药卫生—基础医学]