阿苯达唑对曼氏裂头蚴感染小鼠的疗效观察  

Efficacy of Ablendazole for Treatment of Mice Infected with Sparganum mansoni

作　　者：崔晶 王明明 赵雨薇 甘冠华 胡博文 姜鹏 祁欣 刘莉娜 王中全[1] 

机构地区：[1]郑州大学医学院寄生虫学教研室,郑州450052

出　　处：《中国寄生虫学与寄生虫病杂志》2012年第1期71-72,共2页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(No.30972579);河南省医学科技攻关(No.201003006);郑州大学创新实验计划(No.2011-242)~~

摘　　要：为观察不同剂量阿苯达唑对感染曼氏裂头蚴小鼠的疗效，将72只小鼠随机均分为A～H等8组，每鼠经口感染5条裂头蚴。感染后1周，A～C组小鼠应用阿苯达唑灌胃治疗1个疗程（2次／d×7d），阿苯达唑1个疗程的总剂量分别为1700、2500和3300mg／kg，治疗后1周剖杀；E～G组小鼠治疗1个疗程后间隔7d，再治疗1个疗程，总剂量同A～C组，第2疗程结束后1周剖杀；D、H组小鼠仅灌服蒸馏水，分别作为A～C组和E～G组小鼠的对照组。检获裂头蚴，计算各组小鼠的平均虫数和减虫率。结果发现，A～C组小鼠的减虫率分别为20．0％、20．0％和24．9％，差异无统计学意义（x2=0．351，P〉0．05）。E～G组小鼠的减虫率分别为22-3％、36．4％和31．9％，差异亦无统计学意义（x2=1．812，P〉0．05）；应用相同阿苯达唑剂量治疗1个与2个疗程后，小鼠减虫率的差异均无统计学意义（P〉0．05）。表明阿苯达唑对裂头蚴感染小鼠无明显的治疗效果。In order to observe the efficacy of albendazole for the treatment of mice infected with Sparganum mansoni, a total of 72 mice were divided into 8 groups （9 mice each）, each mouse was orally infected with 5 plerocercoid. At one week after infection, groups A--C were treated with a 7-day course of albendazole （1700, 2500, and 3 300mg/kg, twice daily）, and sacrificed at 1 week post-treatment; groups E-G were treated with the second course of albendazole with the same dosage at 1 week interval after the first course, and sacrificed at 1 week after the second course; the groups D and H were used as control for A-C and E-G, respectively. After the infected mice were sacrificed, the mean number of worms recovered was observed and worm reduction rate was determined. When treating with one course of albendazole at 1 week post infection, the worm reduction rate in groups A-C was 20.0%, 20.0% and 24.9%, respectively （x2=0351, P〉0.05）. After treatment with two courses of albendazole, the worm reduction rate in groups E-G was 223%, 36.4% and 31.9% （X2=L812, P〉0.05）. The difference of the worm reduction rate in the infected mice treated with 1 and 2 courses of albendazole showed no statistical significance （P〉0.05）. The results indicated albendazole has no obvious efficacy for treating sparganosis in mice.

关 键 词：曼氏裂头蚴 裂头蚴病 治疗 阿苯达唑 小鼠 

分 类 号：R532.31[医药卫生—内科学]