葫芦素B抗肿瘤作用及其机制研究进展  

Progress in antitumor effect of cucurbitacin B and its mechanism

作　　者：张延亭[1] 欧阳东云[1] 何贤辉[1] 

机构地区：[1]暨南大学生命科学技术学院组织移植与免疫实验中心,广东广州510632

出　　处：《中国药理学与毒理学杂志》2012年第1期112-115,共4页Chinese Journal of Pharmacology and Toxicology

基　　金：国家自然科学基金(81173604);中央高校基本科研业务费专项资金(21609403)~~

摘　　要：葫芦素是从葫芦科等植物中分离的三萜类天然产物,具有多种药理作用。葫芦素B是葫芦素家族的重要成员,对多种肿瘤具有抑制作用,是潜在的抗肿瘤药物。葫芦素B能够抑制肿瘤细胞STAT3转录因子的活化,干扰丝裂原活化蛋白激酶信号转导通路,诱导细胞周期阻滞于G2/M期,诱导肿瘤细胞凋亡,引起细胞骨架变化。越来越多的研究表明,葫芦素B的抗肿瘤作用可能与其破坏肌动蛋白细胞骨架的活性密切相关。本文综述了葫芦素B的抗肿瘤作用及其可能的机制。Cucurbitacins are a group of diverse triterpenoid compounds,originally isolated from cucurbitaceae plants and having diverse pharmacological and biological activities.As an important member of the cucurbitacins family,cucurbitacin B has inhibitory effects on a variety of tumors and is also a potential antitumor drug.Cucurbitacin B can inhibit activation of the signal transducer and activator of transcription 3,interfere with mitogen-activated protein kinase signaling pathways,cause cell cycle arrest in G2/M phase,and induce apoptosis and cytoskeleton disruption.More studies suggest that cucurbitacin B-induced actin cytoskeleton disruption is closely related to its antitumor activity.The paper reviews the antitumor effect of cucurbitacin B and its possible mechanism.

关 键 词：葫芦素B 抗肿瘤药 STAT3转录因子 细胞骨架 微丝 

分 类 号：R285[医药卫生—中药学]