脑脉络丛组织的连接蛋白、转运蛋白及其药理毒理学研究进展  

Junction proteins and transporter proteins of brain choroid plexus and their research progress in the field of pharmacology and toxicology

作　　者：刘君丽[1,2,3] 敬海明[1,2,3] 李国君[1,2,3] 

机构地区：[1]北京市疾病预防控制中心 [2]北京市预防医学研究中心卫生毒理所,北京100013 [3]首都医科大学公共卫生与家庭医学学院,北京100069

出　　处：《中国药理学与毒理学杂志》2012年第1期120-126,共7页Chinese Journal of Pharmacology and Toxicology

基　　金：北京市留学人员科技活动择优资助项目(2007-62);2007市属公益院所改革与发展项目(2007);北京市"十百千"卫生人才培养专项经费资助("百"层次;2007);北京市"十百千"卫生人才培养专项经费资助("十"层次;2009);北京市卫生系统高层次卫生技术人才培养项目(2011)~~

摘　　要：脑脉络丛组织是血-脑脊液屏障的物质基础,也是脑脊液的重要来源。其上皮细胞之间的紧密连接由连接蛋白组成,是维持细胞间机械屏障的结构基础,不仅具有调节细胞间物质流动和维持上皮细胞极性的功能,而且还参与细胞增殖分化和基因转录等过程的信息传递与调控;其上皮细胞膜上分布的各种转运蛋白,不仅在提供营养和激素等脑组织生长发育所必需的物质、清除脑脊液中的一些有害化合物及代谢物方面起关键作用,而且在药物与毒物的运输调控方面也起着至关重要的作用。这些连接蛋白和转运蛋白构成一个复杂的相互关联的网络结构,在维持脑室生理稳态以及保护脑组织免受内源性和外源性有害物质损害方面发挥着非常重要的作用,近年来备受关注。本文就脑脉络丛组织的连接蛋白、转运蛋白及其药理学与毒理学方面的研究进展作一综述。Choroid plexus tissue is the basis of blood-cerebrospinal fluid barrier within the brain in a variety of species;it is also the major source of cerebrospinal fluid.The tight junction among epithelial cells of choroid plexus is composed of a series of proteins and is the structural foundation of mechanic barriers.Not only can it regulate the flow of substances between cells and maintain the function of cell polarity,but also get involved in cell proliferation and division,genetic information transmission and modulation throughout transcription.A great number of transporters that are usually distributed over cell membrane play an extensive role in nutrition and/or hormones supplement,which are required by normal brain development,toxicants and metabolites scavenge from cerebrospinal fluid,and finally the transportation of drugs and poisons.It is noted that these junction proteins and transporter proteins interact one with another to form a systematic network,which is necessary for stabilizing physiological status in the ventricle and preventing brain tissue from the attack by internal and external toxicants.Therefore,this paper reviewes the function of junction proteins and transporter proteins within choroid plexus and summarizes the research progress that has been made.

关 键 词：脉络丛 血-脑脊液屏障 连接蛋白 转运蛋白 药理 毒理 

分 类 号：R99[医药卫生—毒理学]