不同氧体积分数气体对体外模拟体内生理环境寄养断肢系统血氧分压的影响  

Effect of different oxygen concentrations on blood oxygen pressure in the system of in vitro physiological environment foster limbs

作　　者：王江宁[1] 尹叶锋[1] 高磊[1] 王德成[1] 左有为[1] 苏才培[1] 

机构地区：[1]首都医科大学潞河教学医院,北京市101100

出　　处：《中国组织工程研究与临床康复》2012年第5期855-858,共4页Journal of Clinical Rehabilitative Tissue Engineering Research

摘　　要：背景:断肢再植成功率与断肢的保存方法有直接关系,开展体外模拟体内生理环境寄养断肢的研究,可以延长肢体保存时间。目的:探讨不同氧体积分数对体外模拟体内生理环境寄养断肢系统血氧分压的影响。方法:健康的新西兰绵羊9头,共计36只肢体,行体外断肢同型血液循环灌注实验。36只肢体按照进入膜肺的气体氧体积分数的不同随机数字表均分成氧体积分数100%,60%,50%,40%,20%,10%组进行观察。结果与结论:各组血氧分压数据相比较,氧体积分数10%的动脉血氧分压数值在正常值范围(10.64～13.33kPa),而且动脉血氧分压的数值随氧体积分数的减小而减小。提示在体外模拟体内生理环境寄养断肢系统中,不同氧体积分数的气体进入膜肺可以对动脉血氧分压产生影响,减小氧体积分数可以使动脉血氧分压接近于正常范围。BACKGROUND：Limb replantation success rate with limb preservation method is directly related to conduct in vitro simulated physiological environment foster limbs,which can extend saved time of the limbs.OBJECTIVE：To investigate the effects of different oxygen concentrations on blood oxygen pressure in the system of in vitro physiological environment foster limbs.METHODS：Totally nine New Zealand sheep with a total of 36 limbs underwent in vitro limb perfusion experiments with blood and were randomly divided into six groups according to different concentrations of oxygen gas（100%,60%,50%,40%,20%,10%） into the membrane lung.RESULTS AND CONCLUSION：Comparison of blood oxygen pressure in each group,the arterial oxygen values in experimental group 6 was in the normal range（80-100 mm Hg）,and with the oxygen concentration decreases,arterial oxygen pressure values decreases.It is indicated that in vitro simulation of physiological environment in the foster care system,different concentrations of oxygen gas into the membrane lung may have an impact on the arterial partial pressure of oxygen;through reducing the oxygen concentration,the arterial oxygen pressure can be close to the normal range.

关 键 词：断肢 氧体积分数 体外寄养 模拟人体生理环境 血氧分压 

分 类 号：R318[医药卫生—生物医学工程]