右美托咪啶预先给药对罗哌卡因诱发大鼠心肌毒性阈值的影响  

Effects of dexmedetomidine pretreatment on the threshold for cardiotoxicity induced by ropivacaine in rats

作　　者：贾佳[1] 王班[1] 李艳辉[1] 李红帅[1] 庞磊[1] 王多友[1] 麻海春[1] 

机构地区：[1]吉林大学第一医院麻醉科,长春市130021

出　　处：《中华麻醉学杂志》2011年第12期1434-1436,共3页Chinese Journal of Anesthesiology

摘　　要：目的探讨右美托咪啶预先给药对罗哌卡因诱发大鼠心肌毒性闽值的影响。方法健康Wistar大鼠28只，雌雄不拘，8～12周龄，体重250～350g，采用随机数字表法，将其随机分为4组（n=7）：罗哌卡因组（R组）、低剂量右美托咪啶＋罗哌卡因组（D，组）、中剂量右美托咪啶＋罗哌卡因组（D1组）和高剂量右美托咪啶＋罗哌卡因组（D，组）。D1组、2组和D3组分别经10min静脉输注右美托咪啶5、10、15μg／kg，R组给予等容量生理盐水0．5ml，停止给予右美托咪啶后4组均静脉输注1％罗哌卡因1ml／h至发生心肌毒性。记录发生心肌毒性时罗哌卡因剂量和时间，发生心肌毒性时采集动脉血样，测定血浆罗哌卡因浓度。结果与R组比较，D1组、D2组和D3组罗哌卡因剂量增加，发生心肌毒性时间延长，血浆罗哌卡因浓度升高（P〈0．05）；D1组、D2组和D3组间上述指标差异均无统计学意义（P〉0．05）。结论右美托咪啶预先给药可升高罗哌卡因诱发大鼠心肌毒性的阈值，但是与右美托咪啶剂量无关。Objective To investigate the effects of dexmedetomidine pretreatment on the threshold for car- diotoxicity induced by ropivacaine in rats. Methods Twenty-eight adult Wistar rats of both sexes aged 8-12 weeks weighing 250-350 g were randomly allocated to one of four groups of increasing doses of ropivacaine （ n = 7 each） ： control group （group R） received ropivacaine only and 3 dexmedetomidine groups received dexmedetomidine 5, 10 and 15μg/kg before ropivacaine respectively （groups D1 , D2 , D3 ）. Femoral artery and vein were catheterized for BP monitoring and drug administration. ECG was continuously monitored. Dexmedetomidine was infused over 10 rain via femoral vein in groups D1, D2 and D3 . 1% ropivacaine was infused iv at 1 ml/h until development of cardiac toxicity in group R and at 10 min after dexmedetomidine infusion in groups D1 , D2 and D3 . The onset of cardiotoxicity and the amount of ropivacaine infused were recorded. Plasma concentrations of ropivacaine were measured. Results The onset of cardiotoxicity induced by ropivacaine was significantly slower and amount of ropivacaine and the plasma concentration of ropivacaine were significantly higher in groups Dl , D2 and D3 than in group R, but there were no significant differences among groups D1 , D2 and D3 . Conclusion Dexmedetomidine pretreatment raised the threshold for cardiotoxicity induced by ropivacaine in rats. The cardioprotective effect is not dose-dependent.

关 键 词：右美托咪啶 酰胺类 药物毒性 心肌 

分 类 号：R614[医药卫生—麻醉学]