慢性阻塞性肺疾病急性发作的预防  

Prevention of COPD Exacerbations

作　　者：黄昊[1] 牛颖[1] 鲍贤豪[1] 吴国程[2] 

机构地区：[1]第二军医大学研究生管理大队,上海200433 [2]第二军医大学中医系,上海200433

出　　处：《医学综述》2012年第4期533-535,共3页Medical Recapitulate

摘　　要：慢性阻塞性肺疾病(COPD)患者在其病程中常会出现急性加重的情况,有时需要入院治疗,甚至导致死亡。因此,对稳定期COPD患者实施最佳的治疗有着重要作用。现已证实,单独使用长效支气管扩张剂或联合应用吸入性糖皮质激素,可有效降低COPD患者急性发作的频率。此外,长期应用大环内酯类抗生素也可预防由于支气管细菌移位而致的急性发作,非药物干预措施,也可以有效阻止COPD患者的急性发作,这些均可应用于常规的临床治疗中去。Exacerbations are frequently seen events in the evolution of chronic obstructive pulmonary disease（COPD）,which may lead to hospital admission and even result in death.Therefore,optimizing treatment for stable COPD will help to reduce exacerbations.Long-acting bronchodilators,alone or combined with inhaled corticosteroids,have now been demonstrated efficacy in reducing the rate of exacerbations in patients with COPD.And long-term using of macrolides can suppress exacerbations by bronchial colonisation.Non-pharmacological interventions such as rehabilitation and daily physical activity are also useful strategies to prevent exacerbations in patients with COPD and should be implemented in clinical practice.

关 键 词：慢性阻塞性肺疾病 抗生素 支气管扩张剂 急性发作 

分 类 号：R563.9[医药卫生—呼吸系统]