肾络宁对IgA肾病肾小球硬化大鼠治疗作用的实验研究  

Experimental Study on Effect of Shenluoning on IgA nephropathy glomerulosclerosis Rats Model

作　　者：甄仲[1] 金川[2] 王勋 朱小棣[4] 黄文政[4] 张威[4] 

机构地区：[1]中国中医科学院广安门医院,北京100053 [2]天津市大港医院,天津300000 [3]山东烟台白石肛肠医院,山东烟台264000 [4]天津中医药大学第一附属医院,天津300193

出　　处：《辽宁中医杂志》2012年第3期545-547,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家自然科学基金项目(30472129)

摘　　要：目的:研究肾络宁治疗IgA肾病(IgAN)肾小球硬化模型大鼠的治疗作用。方法:通过切除一侧肾脏,反复注射较大剂量的葡萄球菌肠毒素B(SEB),制作IgAN肾小球硬化大鼠模型,观察肾络宁对大鼠肾脏功能以及病理形态的影响。结果:肾络宁可显著减少尿蛋白、红细胞,改善肾脏功能,减轻肾小球损伤,促进肾脏组织的修复。结论:肾络宁对IgAN肾小球硬化具有较好的防治作用。Objective ： To explore the effect of Shenluoning （SHIN） on IgA nephropathy glomerulosclerosis rats model. Methods ： The model of IgA nephropathy （IgAN） glomerulosclerosis was made by injecting steophylocdccus enterotoxin B （SEB） via rats’ caudal vein repeatedly and unilateral nephrectomy. After feeding for 8 weeks, quantitative analysis of the urine erythrocyte number,24 hour urine protein, blood urine nitrogen （BUN） and serum creatinine （SCr） were performed. The renal pathological analysis and ultrastructure observation were conducted. Results ： Rats with the IgAN glomerulosclerosis showed more proteinuria and deteriorated renal function. While SHLN can effectively decrease the level of BUN, SCr, urine protein, and alleviate glomerulus pathologic injury of IgAN glomerulosclerosis rats. Conclusion ： Shenluoning is an efficient strategy for treating IgAN glomeruloselerosis.

关 键 词：肾络宁 IGA肾病 肾小球硬化 

分 类 号：R285.5[医药卫生—中药学]