银翘柴桂颗粒对流感病毒FM1感染小鼠免疫功能的影响  

Immunomodulatory Effects of Yinqiao Chaigui Granules in mice Infected by Influenza Virus

作　　者：李继庭[1] 左俊岭[2] 林培政[2] 焦英杰[2] 王保华[2] 王林[2] 

机构地区：[1]广东省第二中医院,广东广州510095 [2]广州中医药大学第一附属医院,广东广州510405

出　　处：《辽宁中医杂志》2012年第3期550-552,共3页Liaoning Journal of Traditional Chinese Medicine

基　　金：国家"十二五"科技重大专项"重大新药创制"课题(2011ZX09102-009-06);广东省"211工程"三期学科建设项目

摘　　要：目的:研究银翘柴桂颗粒对流感病毒FM1感染小鼠免疫功能的影响。方法:用甲1型流感病毒FM1鼠肺适应株感染小鼠,建立小鼠流感病毒性肺炎的生物模型,用不同浓度银翘柴桂颗粒溶液治疗后,用ELISA方法检测小鼠血清中IFN-γ及细胞因子IL-2、IL-6含量;中性红比色法测定腹腔巨噬细胞的吞噬能力。结果:银翘柴桂颗粒各剂量组均能明显上调小鼠腹腔巨噬细胞的吞噬能力(P<0.01),而中高剂量组能够提高IFN-γ、IL-2活性,同时抑制IL-6的活性(P<0.05)。结论:银翘柴桂颗粒可通过调节机体的免疫功能发挥抗病毒作用。Objective：To investigate the effects of YinqiaoChaigui granules on immunological function in NIH mice infected by inflenza virus FM1. Methods： The murine pneumonia model was established induced by influenza virus strain A/FM/1/47 （ H1 N1 ）, treated with different dose of YinqiaoChaigui granules. The bioactivities of interferon - γ （ IFN -γ） , interleuking - 2 （ IL -2） and inerleuking -6 in the murine serum were measured by ELISA. The phagocytic function of murinal celiac macrophage was detected by Neutral Red Colorimetry. Results ： Different dose group of YinqiaoChaigui granules upregulated the phagocyte a- bility of murinal celiac maerophage. Medium and high dose group of YinqiaoChaigui granules up - regulated bioaetivity of IFN - yand IL - 2, down - regulated the bioactivity of IL - 6. Conclusion ： YinqiaoChaigui granules has antiviral effects by regulating the immunological function.

关 键 词：银翘柴桂颗粒 流感病毒 免疫调节 

分 类 号：R285.5[医药卫生—中药学]