急性白血病患者血清MCP-1 sIL-2R的检测及临床意义  

Expression and clinical significance of MCP-1、sIL-2R in serum of acute leukemia

作　　者：张文文[1,2,3] 叶翎[1] 

机构地区：[1]济宁医学院附属济宁市第一人民医院,山东济宁272011 [2]济南大学 [3]山东省医学科学院医学与生命学院,山东济南250062

出　　处：《济宁医学院学报》2012年第1期31-32,35,共3页Journal of Jining Medical University

摘　　要：目的探讨急性白血病(Acute Leukemia,AL)患者血清中单核细胞趋化蛋白-1(Monocyte Che-moattractant Protein 1,MCP-1)、可溶性白细胞介素2受体(Solvable Interleukin-2Receptor,sIL-2R)的表达及临床意义。方法采用双抗夹心酶联免疫吸附试验(ELLSA)法,动态测定40例初治AL患者血清中MCP-1、sIL-2R的水平,以20名正常者为对照组。结果初治AL患者血清MCP-1、sIL-2R表达较正常组明显升高(P<0.05);经化疗完全缓解(CR)患者血清中sIL-2R水平较化疗前明显降低,但仍高于正常对照组,完全缓解患者血清中MCP-1水平较化疗前无明显变化(P>0.05),复发患者sIL-2R水平再次升高,复发患者MCP-1水平降低。结论动态监测MCP-1、sIL-2R含量变化有助于预测AL患者的病情变化及评估预后。：Objective To study the expression and Clinical Significance of Monocyte Chemoattractant Protein （MCP-1） ,Solvable Interleukin-2 Receptor （sIL-2R） in Serum of Acute Leukemia（AL）. Methods The serum levels of MCP-I,sIL-2R were dynamically determined with enzyme-linked immunosorbent assay（ELLSA） in 40 newly di- agnosed patients with acute leukemia. Control group was consisted of 20 healthy individuals. Results In 40 newly diagnosed patients, the expression of MCP-1, slL-2R were significantly higher than that in control group （P〈 0.05） ,and sIL-2R decreased after complete remission（CR） but was still higher than that in control group. Howev- er,in relapsed patients it elevated again;The expression of MCP-1 was not significantly different than that in CR patients （P^0. 05）, but in relapsed patients it lowered. Conclusion Dynamically determined the expression of MCP-1 ,sIL-2R cloud help assess the seriousness of the disease and the prognostic Judgment in AL natients.

关 键 词：急性白血病 血清 可溶性白细胞介素2受体 单核细胞趋化蛋白-1 

分 类 号：R557[医药卫生—血液循环系统疾病]