肠球菌属在血液标本的分布及耐药性分析  

Analysis of the isolation and variance of resistance to antibiotics of enterococcus in blood specimens

作　　者：郭主声[1] 张丽华[1] 林偲思[1] 

机构地区：[1]中山大学附属东华医院检验科,广东东莞523110

出　　处：《检验医学与临床》2012年第5期537-538,540,共3页Laboratory Medicine and Clinic

摘　　要：目的探讨肠球菌属在血液标本中的分布与耐药性变迁,为指导临床合理用药,控制感染提供依据。方法对该院2007～2009年临床送检血液标本进行常规培养、鉴定和药敏试验,并用WHONET 5.4软件统计分析这3年间肠球菌临床分离株血液标本、病区中的分布与耐药性的变迁情况。结果共检出肠球菌属细菌62株,菌株以粪肠球菌为主,共33株(53.2%),其次为屎肠球菌25株(40.3%);肠球菌属对红霉素、四环素和青霉素G有较高耐药性,无耐万古霉素的菌株。结论 3年来在细菌种类和耐药方面肠球菌属均发生了较大变化,不同种类的细菌其耐药性差异很大,临床抗感染治疗应以分离菌株的体外抗生素敏感性为依据,合理选用抗生素,以提高其疗效。Objective To study and analyze the isolation and antibiotics-resistance tendency of enterococcus in blood specimens, and in order to guide an appropriate use of antibiotics in clinic and to help carrying on the prevention and therapy of infection. Methods Blood specimens from our hospital during 2007 to 2009 of culture conventional mi- crobiological, bacteria identification and drug sensitivity were tested, WHONET 5.4 soft was used for specimens of changes of distribution and drug resistance. Results 62 strains of enterocoecus were identified, 33 （53.2%）strain was enterococcus faecalis,and the following were E. faecium with 25 strains（40.3%）. The drug resistant rates of en terococcus to erythromycin （ERY）, tetracycline （TET） and penicillin G were rather high, but the enterococci was highly sensitive to vancomycin（VA）. Conclusion Large changes have taken place in the bacterial distribution and drug-resistance of isolated enterococci, and the drug-resistance of strains of enterococci are greatly different during the last 3 years. So the therapy of infection should be based on the antibiotic sensitivity tests in vitro and it is quite necessary to give an appropriate use of antibiotics in clinic for helping carrying on the prevention and therapy of infection.

关 键 词：肠球菌属 血液标本 抗菌药物 耐药性 

分 类 号：R378.1[医药卫生—病原生物学]