旋毛虫致小鼠心肌损伤的试验  

Research on myocardial injury in mice infected with Trichinella spiralis

作　　者：赵风强[1] 韩彩霞[1] 路义鑫[1] 徐佳[1] 张子群 谢晓峰 宋铭忻[1] 

机构地区：[1]东北农业大学动物医学学院,黑龙江哈尔滨150030 [2]黑龙江出入境检验检疫局,黑龙江哈尔滨150036

出　　处：《中国兽医杂志》2012年第2期27-30,I0001,共5页Chinese Journal of Veterinary Medicine

基　　金："十一五"国家科技支撑计划重大项目(2010-BAD04B01);兰州家畜疫病病原生物学国家重点实验室开放课题(SKLVEB2009KFKT005);黑龙江省普通高等学校青年学术骨干支持计划项目(1153G007)

摘　　要：本研究旨在对重度感染旋毛虫后小鼠心肌损伤的研究。通过对小鼠接种旋毛虫,1 000条/只,分别于不同时间对血清中心肌损伤标志物H-FABP、CK-MB和cTnT进行动态检测,以及心肌组织病理形态学变化进行观察。结果显示,H-FABP比CK-MB、cTnT敏感性高(P<0.05),出现及达到高峰的时间最早;感染旋毛虫后19d～24d,心肌组织损伤最为严重。H-FABP可用于早期旋毛虫病患者心肌损伤的诊断,具有较高的敏感性和特异性。This experiment was conducted to study myocardial injury in mice infected with Trichinella spiralis.Each mouse was infected with 1000 of Trichinella spiralis and H-FABP,CK-MB and cTnT were detected in serum and myocardial tissue pathological histological changes were observed.The results showed that H-FABP had higher sensitivity than CK-MB,cTnT（P0.05）,occurred and reached the peak value,after 19~24 d infected with Trichinella spiralis,the most serious injury in myocardial tissue was noted.H-FABP could be used for early high sensitivity and specificity diagnosis of myocardial injury in trichinellosis.

关 键 词：旋毛虫 心肌损伤 H-FABP 

分 类 号：S852.731[农业科学—基础兽医学]