大鼠运动力竭后中性粒细胞粘弹性研究  

INVESTIGATION ON VISCOELASTICITY OF POLYMORPHONUCLEAR NEUTROPHILS IN RAT AFTER EXHAUSTIVE EXERCISE

作　　者：秦廷武[1] 杨瑞芳[2] 蒋稼欢[2] 蔡绍皙[2] 吴云鹏[2] 

机构地区：[1]华西医科大学附一院骨科,成都610041 [2]重庆大学生物工程研究院,重庆400044

出　　处：《中国生物医学工程学报》2000年第1期25-31,共7页Chinese Journal of Biomedical Engineering

基　　金：国家自然科学基金!(3 94 70 2 82 )

摘　　要：本文将多形核中性粒细胞模拟为一各向同性的均质粘弹性球形固体。利用球谐函数法求解大鼠运动力竭前后中性粒细胞在小变形条件下的蠕变问题。理论计算所得的大鼠运动力竭前后中性粒细胞表面位移响应与微管吸吮实验结果吻合较好。本文结果显示大鼠运动力竭后中性粒细胞弹性模量K1 、K2 和粘性系数 μ分别比运动前增加 118%,59%和 71%,提示力竭性运动对中性粒细胞粘弹性有明显影响。文章还对中性粒细胞蠕变问题的时效关系作了研究。Solid spherical harmonic method was used to solve the creep of a rat polymorphonuclear neutrophil modeled as a isotropic and homogeneous spherical solid under small deformation. The calculated surface displacements before and after exhaustive exercise showed an excellent agreement with those obtained by the micropipet aspirating experiment technique. Compared with those of the controls (before exhaustive exercise), the viscoelastic coefficients K 1, K 2 and μ for rat PMNs after exhaustive exercise increased by 118%, 59% and 71%, respectively. These results showed that there was significant effect of exhaustive exercise on viscoelastic properties of neutrophils in rat. The ageing alteration of viscoelastic parameters of rat PMNs also was studied in this paper.

关 键 词：多形核 中性料细胞 粘弹性 力竭性运动 大鼠 

分 类 号：R318.01[医药卫生—生物医学工程] R331.14[医药卫生—基础医学]