小儿难治性癫痫62例药物治疗分析  

The drug treatment of 62 children with intractable epilepsy

作　　者：黄绍平[1] 和光祖[1] 陈征起 李瑞林[1] 何娟 

机构地区：[1]西安医科大学第二临床学院,西安710004

出　　处：《中国实用儿科杂志》2000年第3期163-165,共3页Chinese Journal of Practical Pediatrics

摘　　要：目的　评价抗癫痫药单药大剂量及联合用药治疗小儿难治性癫痫的疗效。方法　在血药浓度监测下对 5 4例患儿投予大剂量卡马西平 (CBZ)或丙戊酸钠 (VPA) ,无效者及呈混合类型发作者采取联合用药方式。结果　单用CBZ者 11%发作获完全控制 ,单用VPA者 15 %发作停止。这些患儿的血药浓度均已达到或超过有效浓度的上限。全组单药或联合用药共 17例 (2 7% )患儿获控制 ,16例 (2 6 % )发作减少 5 0 %以上。结论　难治性癫痫患儿可以采用单药大剂量治疗及联合用药的方法 ,但应注意监测血药浓度 。Objective To evaluate the effectiveness of anti-epileptic drug monotherapy with large dosage and polytherapy in treatment of intractable epileptic children.Methods\ 54 patients received large doses of carbamazepine(CBZ)or valproate acid(VPA)under the monitoring serum concentrations.Those with no effect and with combined seizure types received polytherapy.Results\ Complete seizure control were observed in 11% and 15% of patients with CBZ and VPA treatment separately.Serum concentrations of both drug were in the upper therapeutic range or were above it.In our study seizure free were seen in 27% of patients and more than 50% reduction in seizure was found in 26% of patients.Conclusion\ The monotherapy with large dosage and polytherapy could be considered in intractable cases.But the monitoring of serum levels should be done to avoid over-dose reaction.

关 键 词：儿童 药物疗法 难治性癫痫 

分 类 号：R742.105[医药卫生—神经病学与精神病学]