心肌疾病患儿粒细胞-巨噬细胞集落刺激因子与抗β-受体抗体的关系及其意义  

The relationship between granulocyte-macrophage colony-stimulating factor and autoantibody against β-adrenoceptor in children with myocardial diseases

作　　者：徐灵敏[1] 邹丽萍[1] 岳秋玲 刘松茂[2] 刘清泉[3] 王棣华[1] 栾斌[1] 

机构地区：[1]河南医科大学第三附属医院儿内科,郑州450052 [2]河南医科大学第一附属医院儿科 [3]河南省安阳市人民医院儿科

出　　处：《中国实用儿科杂志》2000年第3期166-167,共2页Chinese Journal of Practical Pediatrics

基　　金：河南省科委资助项目!项目号981170514

摘　　要：目的　探讨病毒性心肌炎 (VMC)和扩张型心肌病 (DCM )患儿粒细胞 -巨噬细胞集落刺激因子 (GM-CSF)与抗 β -肾上腺素受体 (简称 β -受体 )抗体的关系及其意义。 方法　采用放射免疫和免疫印转技术检测了 30例VMC、14例DCM患儿GM -CSF和抗 β -受体抗体。并与对照组 2 5例健康儿对比。 结果　VMC和DCM患儿GM -CSF和抗 β -受体抗体的阳性率分别为 5 4 5 %和 79 5 5 % ,而 2 5例健康儿分别为 8%和 0 (P均<0 0 1) ;且GM -CSF与抗 β -受体抗体的血浆水平呈正相关 (r =0 44 2 3 ,P <0 0 5 )。 结论　GM -CSF和抗 β-受体抗体均参与了VMC和DCM患儿的发病 ,与 β -受体功能异常、心肌自身免疫损伤有关。Objective To investigate the relationship between granulocyte-macrophage colony-stimulating factor(GM-CSF) and autoantibody against myocardial β-adrenoceptor(anti-β)in children with viral myocarditis(VMC)and dilated cardiomyopathy(DCM)and its clinical significance.Methods\ The plasma GM-CSF and anti-β in children(30 with VMC,14 with DCM)were studied with radioimmunoassay and western blot.Results\ The plasma levels of GM-CSF and anti-β in the VMC and DCM group were significantly higher than those in the healthy group(54 55% VS 8% for GM-CSF,P<0 01;79 55% VS 0 for anti-β,P<0 01),and there was positive correlation between GM-CSF and anti-β(r=0 4423,P<0 05).Conclusion\ GM-CSF and anti-β both participate in pathogenesis of VMC and DCM,and were involved in the adnormal function of β-adrenoceptor and the autoimmune injury of myocardium.

关 键 词：心肌病 儿童 GM-CSF β-受体抗体 

分 类 号：R725.422[医药卫生—儿科]