基于机器人机构学的蛋白质多肽链的运动学研究  

Kinematics study of protein polypeptide chain based on robotic mechanisms

作　　者：武江勇[1] 李立[1] 

机构地区：[1]西南交通大学机械工程学院,成都610031

出　　处：《机械设计与制造》2012年第3期96-98,共3页Machinery Design & Manufacture

基　　金：四川省应用基础研究项目(2008JY0063)

摘　　要：使用机器人机构学原理,基于蛋白质多肽链的性质和各原子的位置关系首次将肽键的扭转考虑在内,建立了考虑肽键扭转的蛋白质多肽链的机器人机构学模型。以二级结构中最常见的α螺旋为例进行了仿真,并对其一定的弹性变形进行了计算,仿真和计算结果表明此模型能够更为准确的表达蛋白质二级结构的空间构象,能够准确定位多肽链中原子的空间位置关系,并且此模型在分析多肽链弹性体方面更具合理性。进一步拓展了蛋白质多肽链的机构学模型在蛋白质的二级结构研究中的应用。Considering the twist of peptide bond for the first time,a robotic mechanism model of protein polypeptide chain considering peptide bond twist is established based on the nature of the protein polypeptide chain and the atom positions by applying the thoery of robotic mechanisms.Then α-helix which is the most common in the protein secondary is taken as an example to simulate ,and the plastic deformation is calculated as well.The simulation and calculation illustrate that this model is more precise in simulating the space profile of protein secondary structure,which can confirm precisionly the dimensional position of the atom and is more reasonable in analyzing elastoplasticity.Thus ,the application of the proposed mechanism model is further extencled for the protein polypeptide chain in the study of the protein secondary.

关 键 词：多肽链 肽键扭转 机器人机构学 Α螺旋 

分 类 号：TH16[机械工程—机械制造及自动化] TP24[自动化与计算机技术—检测技术与自动化装置]