血清胱抑素C在早期糖尿病肾病患者肾功能受损评价中的诊断价值  

The meaning of Cystatin C in early diabetic nephropathy diagnosis

作　　者：周连华[1] 范玉娟[1] 姜文娟[1] 何双涛[1] 黎丹凤[1] 

机构地区：[1]复旦大学附属金山医院内分泌科,上海200540

出　　处：《临床内科杂志》2012年第2期108-109,共2页Journal of Clinical Internal Medicine

摘　　要：目的探讨血清胱抑素c在早糖尿病肾病患者肾功能评价中的诊断价值。方法选取114例糖尿病患者，入院测定肾小球滤过率（GFR），根据GFR分为两组：A组47例，GFRl〉90ml／min；B组67例，GFR〈90ml／min。同时测定胱抑素C、肌酐、尿素氮、尿酸、空腹血糖、餐后2小时血糖、糖化血红蛋白（HbAlc）、尿微量蛋白等，比较两组胱抑素C水平，同时分析影响胱抑素c的因素。结果两组间胱抑素c水平比较差异有统计学意义，相关分析显示胱抑素C除了与GFR、尿素氮、尿酸等密切相关外，与年龄、糖尿病病程、HbAlc也密切相关。结论胱抑素c可以作为早期发现糖尿病患者的肾脏损害一个检测指标。Objective TO evaluate the meaning of Cystatin C in early diabetic nephropathy diag- nosis. Methods 114 patients with type 2 diabetes were divided into two groups by glomerular filtration rate（ GFR）, there were 47 patients with GFR more than 90ml/min in A groups,67 patients with GFR less than 90ml/miu in B groups. Cysatin C , serum creatinine（Scr） , blood area nitrogen （BUN）, uric acid（UA）, fasting blood glucose, postprandial blood glucose, glycosylated hemoglobin （HbAle） , urine microalbumin , et al were measured in all patients. Cysatin C was compared between two groups via Ttest; the correlation was analyzed by multivariate correlation analysis. Results Cysatin C levels were sig- nificant higher in A groups than those in B groups. Multivariate correlation analysis showed that Cysatin C was significantly associated with GFR,BUN,UA and also associated with age,diabetes duration , HbAlc. Conclusions Cystatin C could be an early marker in finding diabetic nephropathy.

关 键 词：胱抑素C 糖尿病肾病 

分 类 号：R587.2[医药卫生—内分泌]