不同原因血小板减少症患者促血小板生成素和血清白细胞介素-11水平的检测及意义  

Measurement of serum thrombopoietin levels and serum interlukin-11 levels in patients with thrombocytopenia with different causes and its significance

作　　者：程旭[1] 潘湘涛[1] 王金湖[1] 陆晔[1] 李蓉[1] 严敏[1] 

机构地区：[1]苏州大学附属太仓医院血液科,江苏苏州215400

出　　处：《临床血液学杂志》2012年第2期157-159,共3页Journal of Clinical Hematology

摘　　要：目的:探讨血小板减少症患者血清促血小板生成素(TPO)和白细胞介素-11(IL-11)水平及其与外周血小板计数之间的关系。方法:141例患者分为ITP组、血液肿瘤组和实体肿瘤组3组,应用双抗夹心ABC-ELISA法测定TPO、IL-11,同时用自动血细胞仪测定其血小板数,以30例健康人为正常对照。结果:ITP组、血液肿瘤组和实体肿瘤组的血清TPO水平分别为(130.5±88.3)pg/ml、(103.5±83.9)pg/ml和(148.1±92.5)pg/ml,各组与对照组比较差异无统计学意义。ITP组、血液肿瘤组和实体肿瘤组的血清IL-11水平分别为(46.8±35.8)pg/ml、(40.3±24.7)pg/ml和(44.5±22.3)pg/ml;对照组则为(36.0±18.7)pg/ml。ITP组和实体肿瘤组血清IL-11水平明显高于对照组(均P<0.05)。结论:不同原因血小板减少症患者血清TPO、IL-11水平不一致,检测其有助于了解不同原因血小板减少的可能机制和指导临床治疗。Objective：To investigate levels of endogenous thrombopoietin（TPO）and endogenous interlukin-ll （IL-11）, and the relationships among TPO, IL-11, and peripheral blood platelet counts in patients with thrombocy- topenia. Method：One hundred and forty-one patients were classified into 3 groups including idiopathic thrombocy topenic purpura （ITP） group, hematological malignant patients group, and tumor group. Thirty healthy subjects were enrolled as controls. The levels of TPO and IL-11 were detected in 161 patients with throm bocytopenia and 30 healthy controls by double antibody sandwich enzyme linked immunoso rbent assay（ELISA）, and the results were analyzed statistically. Result： The TPO levels in ITP group, hematological malignant patients group, tumor group and control group were （ 130.5 ±88.3 ） pg/ml, （ 103.5 ± 83.9 ） pg/ml, （ 148.1 ± 92.5 ） pg/ml and （ 138.5± 53.9）pg/ml. Compared with the control group there were not statistically significant. The IL-11 levels in ITP group, hematological malignant patients group, tumor group and control group were （46.8 ± 35.8） pg/ml, （40.3 ± 24. 7）pg/ml, （44.5±22. 3）pg/ml,and （36.0± 18.7）pg/ml. The IL-11 levels in ITP group and tumor group were higher compared to those in control group. Conclusion： The levels of serum TPO and IL-11 in thrombocytopenia pa dents with different causes are different. Detecting the levels of TPO and IL-11 in patients with thromboeytopenia Will contribute to understand the mechanism of thrombocytopenia and direct its clinical therapy.

关 键 词：血小板减少症 促血小板生成素 白细胞介素-11 

分 类 号：R558[医药卫生—血液循环系统疾病]