急性心肌梗死不同梗死部位和病变血管与肌钙蛋白I和NT-proBNP的变化  

Clinical observation to different locations of AMI cTnI and BNP in plasma

作　　者：景舒南[1] 赖碁[1] 杨芳[1] 彭春花[1] 方杰[1] 

机构地区：[1]昆明医学院附属延安医院,650051

出　　处：《中国医学创新》2012年第7期1-3,共3页Medical Innovation of China

摘　　要：目的探讨急性ST段抬高型广泛前壁和下壁心肌梗死,不同梗死部位和相应病变血管血浆心肌肌钙蛋白I和N氨基酸末端脑鈉肽前体的变化。方法 69例急性心肌梗死患者根据心电图、心肌坏死标记物及冠脉造影分为急性ST段抬高广泛前壁心肌梗死组37例和急性下壁心肌梗死组32例。于发病24h内抽取静脉血,行血浆cTnI、NT-proBNP检测。结果急性ST段抬高广泛前壁和下壁心肌梗死血浆cTnI、NT-proBNP均高于正常,且广泛前壁心肌梗死组的cTnI、NT-proBNP高于下壁心肌梗死组,两者比较,NT-proBNP差异有统计学意义(P<0.05),而cTnI差异无统计学意义(P>0.05)。结论 cTnI、NT-proBNP增高可反映急性心肌梗死心肌损害的程度及预后。Objective To explore the relationship between the different locations of acute myocardial infarction with elevated ST segment （STEMI） as well as coronary narrowing and the levels of cardiac troponin I（eTnI） and N - terminal pro - B - typenatriuretic pep- tide（ NT - proBNP） in plasma. Methods Sixty - nine patients of STMI were divided into group - 1 （ n = 37, the infarction was located in the wide anterior wall） and group -2 （n = 32, the infarction was located in the inferior wall） by ECG and coronary angiogram. The cTnI and NT - proBNP in plasma were tested for all of the patients with venous blood samples taken within 24 hours of the AMI. Results The cTnI and NT - proBNP were elevated over the normal level significantly in both of the two groups. That was higher in group - 1 than that of group - 2. The NT - proBNP is significant difference between the two groups （ P 〈 0.05 ） but the eTnI without significant difference （ P 〉 0. 05 ）. Conclusion Both of cTnI and NT - proBNP are risk factors of AMI and may reflect the extent and prognosis of the myocar- dial injury.

关 键 词：急性心肌梗死 心肌肌钙蛋白I 血浆N氨基末端脑鈉肽前体 冠状动脉狭窄 

分 类 号：R542.22[医药卫生—心血管疾病]