肺炎支原体感染与儿童哮喘的相关分析  

Analysis of the relationship between mycoplasma pneumoniae infection and children asthma

作　　者：江月明[1] 涂燕青[1] 莫伟[2] 廖志勤[1] 

机构地区：[1]广东医学院第二附属医院儿科,广东省湛江524003 [2]广东医学院第二附属医院检验科,广东省湛江524003

出　　处：《中国基层医药》2012年第3期371-373,共3页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨肺炎支原体（Mp）感染与儿童哮喘的关系及阿奇霉素治疗的效果。方法选择200例哮喘患儿作为观察对象及50例上呼吸道感染患儿作为对照，采用肺炎支原体抗体检测试验（被动凝集法）检测血清中Mp抗体滴度，同时作全血嗜酸性粒细胞计数；Mp感染阳性哮喘患儿随机分为两组，分别予阿奇霉素和头孢呋辛治疗。结果250例患儿中Mp感染阳性44例，其中哮喘患儿阳性42例，占21％（42／200），哮喘患儿Mp感染率显著高于对照组的4％（2／50）（x2=6．14，P〈0．05）；Mp抗体滴度也显著高于对照组（t=4．38，P〈0．05），且与嗜酸性粒细胞计数呈正相关（r=0．603，P〈0．05）。Mp感染阳性哮喘患儿采用阿奇霉素治疗效果显著高于用头孢呋辛组（x2=16．18，P〈0．05）。结论Mp感染与儿童哮喘的发病密切相关，应尽早常规做Mp抗体测定；阿奇霉素可消除Mp感染，更有利于控制哮喘发作。Objective To study the relationship between mycoplasma pneumoniae （MP） infection and children asthma, and to observe the treatment effects of macrolide antibiotics （azithromycin） on myeoplasma pneumoniae infection. Methods 250 children of respiratory disease were investigated with olimpus electron gastroscope ,200 children asthma;the serum specific antibodies were determined by Diagnostic Kit for measurement of antibodies to mycoplasma pneumoniae（ Passive Particle Agglutination）;and the eosinophilic grannlocytes were serologically analyzed in children with recent asthma. Random selection 42 MP infection positive to macrolides antibiotics（azithromycin） treatment. Results 44 MP infection positive,200 children asthma cases had MP infection with 21% （42/200） MP positive,the specific antibody titers to MP showed significant difference in children with recent asthma compared with those in the eontol group（ x2 = 6.14, P 〈 0.05 ）, and correlated with the count of eosinophilic granulocy positively（ r = 0.603,P 〈 0.05 ） ;The positive rates of specific antibody, infection with MP were significantly higher than those in the control group （ t = 4.38, P 〈 0.05 ）. MP infection positive group with azithromycin treatment effect is significantly higher than that of eefuroxime group （ X2 = 16.18, P 〈 0.05 ）. Conclusion MP infection is closely associated with the pathogenesis of children asthma;and early routine testing for MP antibodies. Macrolides antibiotics can eliminate MP infection,a new generation of maerolides antibiotics（azithromycin） is more advantageous to the control of acute attack of asthma.

关 键 词：肺炎 支原体 哮喘 儿童 阿奇霉素 

分 类 号：R725.6[医药卫生—儿科]