乙二胺毒性研究  

The Toxicity Study of Ethylenediamine

作　　者：王玉芝[1] 尹龙占 刘永珍 夏杰 薄克敏[1] 史丽华[1] 

机构地区：[1]沈阳市劳动卫生职业病研究所

出　　处：《中国公共卫生学报》1990年第2期121-123,共3页

摘　　要：乙二胺急性毒性研究表明,小鼠和大鼠LD_(50)分别为950和840mg/kg;大鼠吸入致死浓度为607ppm,其靶器官为肺、肝、肾。亚急性吸入实验高浓度组(112ppm)动物出现肺、肝、肾病理改变和非特异性免疫功能降低,其阈浓度为2.5ppm。致敏实验豚鼠皮肤发生以单核细胞浸润为主的变态反应性炎症改变,属迟发型过敏反应。Sumary the acute toxicity test of ethylenedia- mine (EDA)showed the mediam lethal dose(LD_(50)) of mouse was 950mg/kg and rats was 840mg/kg.The lethal concentration of inhalation was 607ppmin rats. Its target organs were lung, liver andkidney. In the subacnte inhalation test the animals which inhaled the high concenrtation of EDA (112ppm) resulted the pathologic changes on lung, liver and kidney and reduction of non-specific immunic function the threshold concentration of EDA was 2.5ppm, in the sensitization test, the guinea, pig skin showed the delayed hypensensitivity and infiltration by mononuclear cell with allergic inflammation

关 键 词：乙二胺 毒性 

分 类 号：R135.1[医药卫生—劳动卫生]