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作 者:路艳丽[1] 贺蓉[1] 彭博[1] 徐启华[1] 张旭辉[2] 林含[3] 李建荣[1]
机构地区:[1]中国中医科学院中药研究所,北京100700 [2]北京中医药大学,北京100029 [3]首都医科大学附属北京中医医院,北京100010
出 处:《中国中药杂志》2012年第6期711-714,共4页China Journal of Chinese Materia Medica
基 金:国家"十一五"科技支撑计划项目(2008BAI53B08)
摘 要:目的:比较拔毒生肌散(BDSJS)对不同皮肤损伤条件大鼠肾毒性的差异。方法:采用最低毒性剂量,以肾脏系数、尿β-N-乙酰氨基葡萄糖苷酶(NAG)、视黄醇结合蛋白(RBP)及肾组织形态学为指标,观察BDSJS对破损皮肤和溃疡皮肤模型不同皮肤损伤条件大鼠肾毒性的差异。结果:与破损皮肤相同剂量比较,溃疡皮肤BDSJS高、低剂量组大鼠的肾脏系数、尿RBP含量均见明显升高,肾小管见明显扩张,上皮细胞病变明显;溃疡皮肤BDSJS高剂量组大鼠的NAG含量未见明显升高,低剂量组大鼠的NAG含量见明显升高。结论:在相同给药剂量下,拔毒生肌散对溃疡皮肤大鼠的毒性高于其对破损皮肤大鼠的毒性。Objective: To compare the effects of Badu Shengji San (BDSJS) on rats with different injured skins. Method: The injured and ulcerous skin rat model was established to observe the renal injury induced by BDSJS, a mercury-containing external preparation of Chinese medicine, with urinary N-acetyl-β-D-glucosaminidase (NAG) and retinol binding protein (RBP) as indicators of renal toxicity. Result: Compared to injured skin rats with the same dose, both of high and low-dose ulcerous skin groups showed obvious increase in urinary RBP and kidney coefficients, significant pathomorphological changes in renal tubules and notable epithelial cytopathic effects. In terms of NAG, the high-dose ulcerous skin group saw no significant increase, but the low-dose group recorded sharp rise. Conclusion: The renal toxicity induced by BDSJS in ulcerous skin rats was more toxic than that in injured skin ones.
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