心力衰竭大鼠不同时期尾加压素Ⅱ、内皮素-1和肾上腺髓质素水平变化及益气温阳活血方对其影响的研究  

Effects of decoction of yiqiwenyanghuoxue on UII,ET-1,ADM in the rats with early heart failure

作　　者：杨冬花 罗建华[1] 袁志柳[1] 付蓉[2] 

机构地区：[1]贵州省人民医院干医科,贵阳550002 [2]贵阳中医学院第二附属医院心内科,550003

出　　处：《贵州医药》2012年第1期4-7,共4页Guizhou Medical Journal

基　　金：贵州省教育厅自然科学研究项目(黔科教2008028号);贵州省中医药管理局科技课题(黔中医药发[2009]79号);贵州省科技计划项目(黔科合SY[2010]3121号);贵阳市科技计划项目([2010]筑科农合同字第1-社-37号)

摘　　要：目的探讨中药复方益气温阳活血方对早期心力衰竭大鼠血浆尾加压素Ⅱ(UII)、内皮素-1(ET-1)和肾上腺髓质素(ADM)的变化。方法以阿霉素尾静脉注射造模;超声检测评价其心功能、应用放射免疫法检测血浆UⅡ、ET-1、ADM水平在益气温阳活血方治疗前后的变化。结果随着心衰的加重、心室重构形成,模型大鼠血浆ET-1、ADM水平则进性升高,而UⅡ水平进行性降低,益气温阳活血方在心力衰竭的早期即可降低ET-1、ADM水平及升高UⅡ水平。结论UⅡ、ET-1、ADM可作为早期心衰预警标志物;益气温阳活血方通过影响UⅡ、ET-1、ADM的水平,防止心室重塑,改善心脏功能。Objective To investigate the effects of decoction of yiqiwenyanghuoxue on UII,ET-1,ADM in the rats with early heart failure.Methods The model rats with chronic heart failure（CHF） were injected with Adriamycin and and treated by decoction of yiqiwenyanghuoxue,then UII,ET-1,ADM levels were detected by radio-immunity.Results Compared to the control group,ET-1,ADM levels were significant-ly higher,but UII levels were significantly lower in CHF groups,and those bing higher or lower when heart failure bing aggravating and myocardial remodel-ing.But those can be attenuated by decoction of yiqiwenyanghuoxue.Conclusion UII,ET-1,ADM can be the predictors in early heart failure.Decoction of yiqiwenyanghuoxue can prevent myocardial remodeling and improve heart function through regulating UII,ET-1,ADM levels.

关 键 词：早期心力衰竭 尾加压素Ⅱ 内皮素-1 肾上腺髓质素 益气温阳活血方 

分 类 号：R541.6[医药卫生—心血管疾病]