微波辐射下SbCl_3催化的喹唑啉酮衍生物的合成  

Synthesis of Quinazolin-4(3H)-one Derivatives Catalyzed by SbCl_3 under Microwave Irradiation

作　　者：周建华[1] 王伟立[1] 刘晓霞[1] 张纪明[1] 

机构地区：[1]山东轻工业学院化学与制药工程学院,山东济南250353

出　　处：《山东科技大学学报（自然科学版）》2012年第1期67-70,共4页Journal of Shandong University of Science and Technology(Natural Science)

基　　金：山东省自然科学基金项目(Y2008B33)

摘　　要：在微波辐射下,以三氯化锑(SbCl3)作为催化剂促进2-氨基苯甲酰胺和各种酰胺缩合反应,高效地合成了4(3H)-喹唑啉酮衍生物。产品经测定熔点、核磁共振氢谱、红外光谱等方法得到确认。目标产物经过乙醇重结晶纯化,收率在65%～92%。最优合成条件为:反应物在微波700W辐射10min,催化剂用量为10%(以邻氨基苯甲酰胺的mol量计算)。此方法具有反应时间短、操作简单、环境友好等优点。Antimony trichloride（SbCl3） was taken as an effective catalyst for the condensation reaction of 2-anthranilic amide with various amides to obtain the quinazolin-4（3H）-one derivatives under microwave irradiation.The products were identified by means of 1H NMR,IR spectroscopy and measurement of melting points.The target products are purified by recrystallization from ethanol and their output is ranging from 65% to 92%.This method showed the advantages of a short reaction time,simple manipulations and friendly environment.

关 键 词：三氯化锑 4(3H)-喹唑啉酮衍生物 缩合反应 微波辐射 

分 类 号：O621.3[理学—有机化学]