抗疲劳中药对小鼠抗疲劳及调节免疫作用的研究  

Effects of Herbs Compound on Immunity Function and Anti-tiredness in Mice

作　　者：陈利平[1] 吴整军[1] 仝战旗[1] 钱妍[1] 段冬梅[1] 臧倩[1] 

机构地区：[1]中国人民解放军总医院南楼中医针灸科,北京100853

出　　处：《中华中医药学刊》2012年第3期493-494,共2页Chinese Archives of Traditional Chinese Medicine

基　　金：国家科技支撑计划资助项目(2009BAI86B04)

摘　　要：目的:探讨益气健脾、补肾调理复方中药对小鼠抗疲劳能力和免疫调节的作用。方法:6周龄清洁级昆明种小鼠随机分为4组:生理盐水组对照组、抗疲劳中药复方高、中、低剂量组,小鼠进行适应性运动训练1周,进行动物实验,每日灌胃1次,用药2周,通过爬竿试验、游泳试验、吞噬指数、免疫器官质量法(胸腺指数和脾脏指数)观察益气健脾、补肾调理中药复方抗疲劳的作用和增强免疫功能的作用。结果:抗疲劳中药复方能延长小鼠负重游泳的时间、延长爬竿时间,尤其是高剂量抗疲劳中药复方组能明显延长小鼠负重游泳持续时间,与生理盐水组比较有显著性差异,(P<0.05);抗疲劳中药复方能增强巨噬细胞吞噬功能、脾脏指数(P<0.05)。结论:抗疲劳中药复方具有增强小鼠抗疲劳能力和免疫功能作用。Objective ： To investigate the effects of herbs compound on immunity function and anti - tiredness in mice. Method：Healthy mice aged 6 weeks were randomly divided into 4 groups, that is：0.9% NS control group,herbs compound decoction high, middle and low dosage group. In order to observe the effects of herbs compound on anti - tiredness and immunity function, after treating 2 weeks and adaptive training for l week, the indexes of the pole test, loading swimming test, and phagocytes＇index, and immune organs weight （spleen index and the thymus index） were detected. Result：The herbs compound could increase the continual loading swimming and climbing time markedly, and the difference between higher dose group and NS group was significantly increased （P 〈 0.05 ）. Compared with NS group, higher dose herbs group also could enhance mouse clearance capacity index and improve the spleen index （ P 〈 0. 05 ）. Conclusion：The higher dose group herbs compound has obvious effects on enhancing the mouse abilities on anti - tiredness and improving the mouse immune function.

关 键 词：中药复方 吞噬指数 胸腺指数 脾脏指数 抗疲劳 

分 类 号：R285.5[医药卫生—中药学]