清肝宁肺汤对咳嗽变异性哮喘模型大鼠IgE、IL-6、ICAM-1影响的实验研究  

Study on Effect of Qinggan Ningfei Decoction on CVA Rat′s IgE、IL-6、ICAM-1

作　　者：葛资宇[1] 童骄[1] 朱文雄[1] 曾逸笛[1] 卢芳国[2] 

机构地区：[1]湖南中医药大学2007级中西医结合系,湖南长沙410208 [2]湖南中医药大学,湖南长沙410208

出　　处：《中华中医药学刊》2012年第3期596-598,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：湖南省大学生研究性学习和创新性实验计划项目(2010-165);湖南省大学生研究性学习和创新性实验计划项目(2011-173);湖南省普通高等学校教学改革研究项目(2011-177);湖南省学位与研究生教育教改研究项目(JG2011B030)

摘　　要：目的:探究清肝宁肺汤治疗咳嗽变异性哮喘(CVA)的部分作用机制。方法:利用卵蛋白(OA)及辣椒素,复制CVA大鼠模型,分为正常对照组、模型对照组、地塞米松片组、清肝宁肺汤组、地塞米松片合清肝宁肺汤组(以下简称为中西医结合组),以引喘诱咳时2min内大鼠咳嗽次数及血清中IL-6、IgE及ICAM-1的含量为指标。结果:与正常对照组比较,模型对照组咳嗽次数明显增多(P<0.01),血清中IgE、IL-6、ICAM-1含量显著升高(P<0.01)。经治疗后清肝宁肺汤组咳嗽次数明显减少(P<0.01),血清上述指标含量明显降低(P<0.01)。结论:清肝宁肺汤通过降低机体IgE、IL-6、ICAM-1的含量发挥治疗CVA作用。Objective： Qinggan Ningfei Decoction treating mechanisms of the cough variant asthma were studied. Methods： By ovalbumin （OA） and belly cavity, CVA rat model was made and divided into normal matched control group, model matched control group, dexamethasone tablet grtoup,Qinggan Ningfei Dection Cough times 2 mins and the contents of IL - 6, IgE and ICAM - 1 in the serum were used for index sign. Results ： Compared with the normal control group, model matched control~ cough number obviously increased （ P 〈 0.01 ）, the content of IgE, IL -6 and ICAM - 1 showed （ P 〈0.01 ）. After treatment, Qinggan Ningfei Decoction cough number obviously reduced（ P 〈0.01 ）, the se- rum above -mentioned index sign content obviously decreased （ P 〈 0.01 ）. Conclusion： Treatment of Qinggan Ningfei Decoction CVA can get good results by reducing the body＇ s IgE, IL - 6, ICAM - 1 concentration.

关 键 词：咳嗽变异性哮喘 免疫球蛋白-E(IgE) 白细胞介素-6(IL-6) 细胞间黏附因子-1(ICAM-1) 清肝宁肺汤 

分 类 号：R285.5[医药卫生—中药学]