巯基-烯点击化学  

Thiol-Ene Click Chemistry

作　　者：徐源鸿[1] 熊兴泉[1] 蔡雷[1] 唐忠科[1] 叶章基[2,3] 

机构地区：[1]华侨大学材料科学与工程学院福建省高校功能材料重点实验室,厦门361021 [2]中国船舶重工集团公司第七二五研究所厦门分部,厦门361002 [3]海洋腐蚀与防护国防科技重点实验室,厦门361002

出　　处：《化学进展》2012年第2期385-394,共10页Progress in Chemistry

基　　金：国防重大安全基础研究(国防973)项目(No.61310903);国家自然科学基金项目(No.21004024);福建省"高校杰出青年科研人才培育计划"(No.11FJPY02);福建省自然科学基金项目(No.2011J01046)资助

摘　　要：点击化学自2001年由Sharpless提出后,由于其高效、可靠、高选择性的特点迅速成为药物和高分子材料合成的新方法。随着对点击化学研究的深入,其反应类型在不断增多,应用范围也在不断扩大。自由基或亲核试剂引发的巯基-烯反应作为其中一种新型的点击反应具有点击化学的所有特性。本文从点击化学的概念、特征和类型出发,重点介绍了巯基-烯反应的机理和在合成功能聚合物、制备拓扑结构高分子、表面修饰以及生物药物等方面的应用,并对巯基-烯反应的最新研究成果进行综述,最后展望了巯基-烯的点击化学的发展前景。＂Click chemistry＂, introduced by Sharpless in 2001, becomes a new synthetic method used in areas such as drugs, polymers and materials rapidly because of its high efficiency, high selectivity and reliable characteristics. With the further research on click chemistry, the types of it are increasing continuously and the scope of application is also expanding. Radical-mediated or nucleophile-initiated thiol-ene reaction is a novel kind of click reactions, which shows the characteristics of click chemistry. Starting from the concept, characteristic and types of click chemistry, the mechanism and the wide applications of thiol-ene reaction in preparation of functional polymers and topologic macromolecules, polymeric materials surface modification and biomaterials are emphasized. Furthermore, the latest research based on thiol-ene chemistry is summarized. The prospects of thiol-ene reaction are also discussed.

关 键 词：点击化学 巯基-烯反应 功能聚合物 拓扑结构 表面修饰 生物分子 

分 类 号：O631.5[理学—高分子化学] O633.3[理学—化学]