急性荨麻疹患者血清ECP、tIgE、sIgE检测及意义  

Detection of Eosinophil Cationic Protein,Total IgE and Allergen Specific IgE in Patients with Acute Urticaria

作　　者：赵俊芳[1] 李桂珍[1] 赵宏丽[1] 李孟娟[1] 

机构地区：[1]天津市中医药研究院附属医院,天津300120

出　　处：《中国中西医结合皮肤性病学杂志》2012年第1期30-32,共3页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的通过检测荨麻疹患者及正常对照组血中嗜酸性粒细胞阳离子蛋白(ECP)、总IgE(tIgE)及变应原特异性IgE(sIgE)的水平,探讨其变化在荨麻疹发生发展中的重要意义。方法采用酶联免疫法检测248例荨麻疹患者及40名正常对照者血清ECP、tIgE浓度,采用免疫印迹法检测其sIgE的水平,并对检测结果进行统计学分析。结果荨麻疹患者ECP、tIgE浓度明显高于正常对照者(P<0.05);荨麻疹患者治疗2个月后ECP水平明显下降(P<0.05);248例患者中,178例患者至少对一种变应原呈阳性反应(71.77%),有135例患者对2～7种变应原呈阳性反应(54.43%),正常对照者的sIgE检测全部为阴性。结论 ECP、tIgE、sIgE检测对了解该病的发病机制、病因、病情严重程度具有一定意义。Objective To explore the roles and clinical significance of eosinophil cationic protein（ECP）,total IgE（tIge）and allergen specific IgE in patients with urticaria.Methods Serum concentration of ECP and tIgE was detected in 248 patients with urticaria and 40 normal controls by enzyme-linked immuno sorbent assay（ELISA）,and allergen specific IgE was detected by immunoblotting method.Results Serum ECP and total IgE was significantly higher in urticaria patients than those in normal controls（P0.05）;and the ECP level was significantly decreased two months after therapy.178 patients with urticaria were allergic to one allergen at least（71.77%）,while the allergen specific IgE of normal controls were negative.Conclusion Detection of ECP,total IgE and allergen specific IgE is meaningful for comprehending the pathogenesy,etiopathogenisis and severity of urticaria.

关 键 词：荨麻疹 嗜酸性粒细胞阳离子蛋白 总IGE 变应原特异性IgE 

分 类 号：R758.23[医药卫生—皮肤病学与性病学]