光动力学及激光治疗子宫颈持续性HPV感染的疗效比较  

Comparison of photodynamic therapy with laser therapy for human papillomavirus infection in cervix

作　　者：姚红霞[1] 王玲[1] 吴红[1] 孙黛丽[1] 

机构地区：[1]同济大学附属第一妇婴保健院宫颈病中心,上海200050

出　　处：《同济大学学报（医学版）》2012年第1期63-66,共4页Journal of Tongji University(Medical Science)

基　　金：上海市浦东新区社会发展局卫生科技项目(PW2009D-8)

摘　　要：目的与传统激光比较,探讨光动力学治疗法在治疗子宫颈持续性人乳头瘤样病毒(human papillomavirus,HPV)感染中的价值。方法 2008年12月至2010年4月在我院经HPV DNA杂交捕获试验证实存在HPV感染,且感染持续一年以上的患者共126例,分别采用光动力学法和激光治疗法进行治疗,将两者的疗效进行比较。结果光动力学治疗组76例,治疗后3个月进行HPV-DNA检测时,有56例转阴性,转阴率为73.68%;其中46例合并CINI的患者,36例治愈,治愈率为78.3%。激光治疗组50例,治疗后3个月进行HPV-DNA检测,有31例转阴性,转阴率为62.0%。两种方法比较,P>0.05,差异无显著性。结论与传统激光治疗法相比,光动力学治疗法也是治疗子宫颈持续性HPV感染及早期宫颈上皮瘤样病变的有效方法,同时具有损伤小、可重复治疗的优点。Objective To compare the photodynamic therapy with laser therapy for human papillomavirus （HPV） infection in cervix. Methods Total 126 patients with human papillomavirus infection in cervix were treated with photodynamic therapy （76 cases） or laser therapy （50 cases） from December 2008 to April 2010. The therapeutic results were evaluated three months after treatment. Results In photodynamic therapy group the HPV negative conversion rate was 73.7% （56/76） 3 months after treatment, while the virus negative conversion rate in laser therapy group was 62.0% （36/50）. There was no significant difference between two groups. Conclusion Compared with laser therapy, photodynamic therapy is an effective and repeatable method for treatment of HPV infection in cervix, with less adverse effects.

关 键 词：光动力学治疗法 激光治疗 人乳头瘤样病毒 宫颈 

分 类 号：R713[医药卫生—妇产科学]