羊水中多能性干细胞的培养及分化  

Culture and differentiation of pluripotent stem cells from amniotic fluid

作　　者：罗成凤[1] 周倩[1] 

机构地区：[1]同济大学附属第一妇婴保健院中心实验室,上海200040

出　　处：《同济大学学报（医学版）》2012年第1期113-116,共4页Journal of Tongji University(Medical Science)

基　　金：上海市自然科学基金(10ZR1423500);上海市卫生局科研项目(2008008)

摘　　要：羊水中存在多能性干细胞,它们不仅阳性表达胚胎干细胞(embryonic stem cell,ESC)表面标志物,如SSEA-4,保持未分化状态的转录因子OCT-4,胚胎多能性维持因子Nanog等;而且阳性表达成人干细胞(adult stem cell,ASC)表面标志物CD29和CD44等,在特定的诱导条件下能够分化为代表三胚层生殖层系。Human amniotic fluid contains pluripotent stem cells, which positively express markers of embryonic stem cells, like SSEA-4, Oct-4 and Nanog; and also markers of adult stem ceils, like CD29 and CD44. Under specific inducing conditions, they are capable of differentiating into lineages representing three embryonic germ layers.

关 键 词：羊水 多能性干细胞 培养 分化 

分 类 号：R713[医药卫生—妇产科学]