年龄、性别、糖尿病史对脑葡萄糖标准化摄取最大值和标准化代谢率的影响  

Age, gender and history of diabetes influencing maximum standardized uptake value and standardized cerebral metabolic rate of glucose

作　　者：吴坚[1] 练学淦[1] 沙络林[1] 杨松[1] 盛世英[1] 朱林凤[1] 杨志龙[1] 朱虹[2] 

机构地区：[1]常州市第一人民医院神经内科,213003 [2]南京军区南京总医院核医学科,南京 210002

出　　处：《中华神经医学杂志》2012年第3期297-303,共7页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金（81070923）

摘　　要：目的研究年龄、性别、糖尿病史对脑葡萄糖代谢标准化摄取最大值（SUVmax）及标准化代谢率（SCMR）的影响。方法选取自2006年5月至2010年11月在南京军区南京总医院核医学科行PET-CT脑代谢体检的健康志愿者79例，采用感兴趣区法分别测量双侧大脑、小脑各13个感兴趣区（左右侧a1、a2、m1、m2、m3、m4、m5、m6、in、CS、p1、p2、ce）的SUVmaX值，通过计算左侧感兴趣区SUVmax值／右侧相应感兴趣区SUVmax值得到SCMR值。对受检者进行分层分析，分为男性组（45例）和女性组（34例），〈40岁组（33例）、40-49岁组（21例）和≥50岁（25例），糖尿病组（26例1和非糖尿病组（53例1，探讨不同年龄段、不同性别、有无糖尿病史对SUVmax值和SCMR值的影响。结果受检者左右侧间各相应感兴趣区的SUVmax值比较差异均无统计学意义（P〉0．05），左右侧半球中各感兴趣区间SUVmax值比较差异有统计学意义（左侧：F=14．280，P=0．000；右侧：F=14．680，P=0．0001。女性左右侧m1感兴趣区的SUVmax值明显低于男性，差异有统计学意义（P＜0．05）。不同年龄组间左右侧各感兴趣区的SUVmax值比较差异均有统计学意义（P＜0．05）。糖尿病组左侧a1、右侧a1、左侧a2、右侧a2、右侧m2、左侧m3、左侧m4、右侧m4、左侧p1、右侧p1、左侧p2、右侧p2、左侧CS、右侧CS、左侧in、右侧in、左侧ce、右侧ce共18个感兴趣区的SUVmax值低于非糖尿病组，差异有统计学意义（P〈0．05）。但经标准化处理后，不同性别、不同年龄段、有无糖尿病组间各感兴趣区的SCMR值比较差异均无统计学意义（P〉0．05）。结论SUVmax值受年龄、性别、糖尿病史等因素的影响，而应用SCMR值可以消除上述因素的影响，为不同研究或不同个体之间的比较提供一个可靠的研究指标。Objective To study the influence of age, gender and history of diabetes in maximum standardized uptake value （SUVmax） and standardized cerebral metabolic rate （SCMR） of glucose. Methods Seventy-nine healthy volunteers were recruited and evaluated by PET-CT examination. Region of interest （ROI） analysis was employed to measure the SUVmax in 13 ROIs of the brain and 13 ROIs of the cerebellum. SCMR was amounted by left SUVmax/right SUVmax in the corresponding ROI point of each side in the same volunteer. The influences of age, gender and history of diabetes in SUVmax and SCMR were analyzed. Results No statistical significance of SUVmax was noted between the 2 corresponding points in bilateral ROI （P〉0.05）. Statistical significance of SUVmax was noted between each 2 points in the left and right ROI （left： F=14.280, right： F=14.680, P=0.000）. Statistical difference of SUVmax was recorded in different age groups （P〈0.05）. The female had significantly lower SUVmax inbilateral measurement points （2/26） as compared with the male （P〈0.05）. Concerning the influence of history of diabetes, statistical significance of SUVmax was noted in almost all ROIs （18/26, P〈0.05）. No statistical significance of SCMR in each ROI was noted in different groups of gender, age and diabetes （P〉0.05）. Conclusion SCMRglu can eliminate the role of such influencing factors as age, gender and history of diabetes, which have been proved to exert some effect on the results of SUVmax; therefore, SCMRglu may provide a reliable indicator for further study.

关 键 词：正电子发射断层扫描 脑葡萄糖 标准化摄取最大值 标准化代谢率 感兴 趣区 

分 类 号：R587.1[医药卫生—内分泌]